Ramírez-Bueno, ASalazar-Ramírez, CCota-Delgado, FTorre-Prados, M V de laValdivielso, P2015-04-162015-04-162014-02Ramírez-Bueno A, Salazar-Ramírez C, Cota-Delgado F, Torre-Prados MV de la, Valdivielso P. Plasmapheresis as treatment for hyperlipidemic pancreatitis. Eur. J. Intern. Med.. 2014 ; 25(2):160-30953-6205http://hdl.handle.net/10668/1874Journal Article;BACKGROUND Severe hypertriglyceridemia with an accumulation of chylomicrons and triglyceride figures >1000 mg/dL can cause acute pancreatitis, a potentially fatal complication. The option of rapid reduction in triglyceride concentrations is attractive and possible with plasmapheresis. METHODS We present the results of an analysis of 11 patients admitted to the intensive care unit with severe hypertriglyceridemic pancreatitis and treated with plasmapheresis. The procedure was repeated until serum triglycerides were below 1000 mg/dL. We recorded anthropometric, clinical data as well as final outcome. RESULTS In eight patients a single plasma exchange was sufficient to reduce triglyceride figures <1000 mg/dL. Only three patients died, all with the worst severity indexes and who experienced the longest delay before the procedure. CONCLUSIONS Our results, together with a review of the literature, confirm the need for a randomized clinical trial to compare conventional treatment vs. plasmapheresis in patients with severe hypertriglyceridemic pancreatitis.enPlasmapheresisAcute pancreatitisHypertriglyceridemic pancreatitisSevere hypertriglyceridemiaPlasmaféresisPancreatitisHiperlipidemiasEnfermedad agudaÍndice de severidad de la enfermedadResultado del tratamientoMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Blood Component Removal::PlasmapheresisMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias::HyperlipidemiasMedical Subject Headings::Diseases::Digestive System Diseases::Pancreatic Diseases::PancreatitisMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Acute DiseaseMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Health Status Indicators::Severity of Illness IndexMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment OutcomeMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humansresearch article24012324open access10.1016/j.ejim.2013.08.7011879-0828