Ibáñez-Casas, InmaculadaPortugal, Enrique deGonzález, NievesMcKenney, Kathryn AHaro, Josep MUsall, JudithPérez-García, MiguelCervilla, Jorge A2015-08-062015-08-062013-08Ibáñez-Casas I, Portugal E de, González N, McKenney KA, Haro JM, Usall J, et al. Deficits in executive and memory processes in delusional disorder: a case-control study. PLoS ONE. 2013; 8(7):e67341http://hdl.handle.net/10668/1948Journal Article; Research Support, Non-U.S. Gov't;OBJECTIVE Delusional disorder has been traditionally considered a psychotic syndrome that does not evolve to cognitive deterioration. However, to date, very little empirical research has been done to explore cognitive executive components and memory processes in Delusional Disorder patients. This study will investigate whether patients with delusional disorder are intact in both executive function components (such as flexibility, impulsivity and updating components) and memory processes (such as immediate, short term and long term recall, learning and recognition). METHODS A large sample of patients with delusional disorder (n = 86) and a group of healthy controls (n = 343) were compared with regard to their performance in a broad battery of neuropsychological tests including Trail Making Test, Wisconsin Card Sorting Test, Colour-Word Stroop Test, and Complutense Verbal Learning Test (TAVEC). RESULTS When compared to controls, cases of delusional disorder showed a significantly poorer performance in most cognitive tests. Thus, we demonstrate deficits in flexibility, impulsivity and updating components of executive functions as well as in memory processes. These findings held significant after taking into account sex, age, educational level and premorbid IQ. CONCLUSIONS Our results do not support the traditional notion of patients with delusional disorder being cognitively intact.enNeuropsychological TestsSchizophrenia, ParanoidMental RecallVerbal LearningPruebas neuropsicológicasEsquizofrenia paranoideRecuerdo mentalAprendizaje verbalEstudios de casos y controlesEscolaridadFunción EjecutivaMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Age FactorsMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::AgedMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control StudiesMedical Subject Headings::Health Care::Population Characteristics::Socioeconomic Factors::Educational StatusMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Executive FunctionMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Memory::Mental RecallMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle AgedMedical Subject Headings::Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Neuropsychological TestsMedical Subject Headings::Psychiatry and Psychology::Mental Disorders::Schizophrenia and Disorders with Psychotic Features::Schizophrenia::Schizophrenia, ParanoidMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Sex FactorsMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Verbal LearningMedical Subject Headings::Named Groups::Persons::Age Groups::Adultresearch article23844005open access10.1371/journal.pone.00673411932-6203PMC3699582