Navas Alcántara, María SierraMontero Rivas, LorenaGuisado Espartero, María EstherRubio-Rivas, ManuelAyuso García, BlancaMoreno Martinez, FranciscoAusín García, CristinaTaboada Martínez, María LuisaArnalich Fernández, FranciscoMartínez Murgui, RaúlMolinos Castro, SoniaRamos Muñoz, Maria EstherFernández-Garcés, MarCarreño Hernandez, Mari CruzGarcía García, Gema MaríaVázquez Piqueras, NuriaAbadía-Otero, JesicaLajara Villar, LourdesSalazar Monteiro, CristinaPascual Pérez, María de Los ReyesPerez-Martin, SantiagoCollado-Aliaga, JavierAntón-Santos, Juan-MiguelLumbreras-Bermejo, Carlosen nombre del grupo SEMI-COVID-192023-05-032023-05-032021-11-15http://hdl.handle.net/10668/22369Smoking can play a key role in SARS-CoV-2 infection and in the course of the disease. Previous studies have conflicting or inconclusive results on the prevalence of smoking and the severity of the coronavirus disease (COVID-19). Observational, multicenter, retrospective cohort study of 14,260 patients admitted for COVID-19 in Spanish hospitals between February and September 2020. Their clinical characteristics were recorded and the patients were classified into a smoking group (active or former smokers) or a non-smoking group (never smokers). The patients were followed up to one month after discharge. Differences between groups were analyzed. A multivariate logistic regression and Kapplan Meier curves analyzed the relationship between smoking and in-hospital mortality. The median age was 68.6 (55.8-79.1) years, with 57.7% of males. Smoking patients were older (69.9 [59.6-78.0 years]), more frequently male (80.3%) and with higher Charlson index (4 [2-6]) than non-smoking patients. Smoking patients presented a worse evolution, with a higher rate of admission to the intensive care unit (ICU) (10.4 vs 8.1%), higher in-hospital mortality (22.5 vs. 16.4%) and readmission at one month (5.8 vs. 4.0%) than in non-smoking patients. After multivariate analysis, smoking remained associated with these events. Active or past smoking is an independent predictor of poor prognosis in patients with COVID-19. It is associated with higher ICU admissions and in-hospital mortality.enCOVID-19HospitalizadoHospitalizedMortalidadMortalitySARS-CoV-2SmokingTabaquismoAgedCOVID-19HospitalizationHumansIntensive Care UnitsMaleRegistriesRetrospective StudiesSARS-CoV-2research article34895891open access10.1016/j.medcli.2021.10.0111578-8989PMC8590935https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590935https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590935/pdf