Blanco-Rojo, RuthAlcala-Diaz, Juan F.Wopereis, SuzanPerez-Martinez, PabloQuintana-Navarro, Gracia M.Marin, CarmenOrdovas, Jose M.van Ommen, BenPerez-Jimenez, FranciscoDelgado-Lista, JavierLopez-Miranda, Jose2023-02-122023-02-122015-09-08Blanco-Rojo R, Alcala-Diaz JF, Wopereis S, Perez-Martinez P, Quintana-Navarro GM, Marin C, et al. The insulin resistance phenotype (muscle or liver) interacts with the type of diet to determine changes in disposition index after 2 years of intervention: the CORDIOPREV-DIAB randomised clinical trial. Diabetologia. 2016 Jan;59(1):67-760012-186Xhttp://hdl.handle.net/10668/18621Aims/hypothesis The aim of the study was to determine whether basal insulin resistance (IR) phenotype (muscle and/or liver) determines the effect of long-term consumption of a Mediterranean diet or a low-fat diet on tissue-specific IR and beta cell function.Methods The study was performed in 642 patients included in The effect of an olive oil rich Mediterranean diet on type 2 diabetes mellitus risk and incidence study (CORDIOPREVDIAB). A total of 327 patients were randomised to a Mediterranean diet (35% fat; 22% from monounsaturated fatty acids) and 315 to a low-fat diet (<28% fat). At baseline, the patients were classified into four phenotypes according to the type of IR: (1) no IR; (2) muscle IR; (3) liver IR; (4) muscle+liver IR. The hepatic insulin resistance index (HIRI), muscular insulin sensitivity index (MISI) and disposition index were analysed at baseline and after 2 years of follow-up. Results At baseline, 322 patients presented no IR, 106 presented muscle IR, 109 presented liver IR, and 105 presented muscle+liver IR. With both dietary interventions, HIRI decreased in all patients (p<0.001) and MISI increased in muscle IR and muscle+liver IR patients (p<0.01). Long-term intake of the Mediterranean diet increased the disposition index and insulinogenic index in the muscle IR patients (p=0.042 and p=0.044, respectively) and the disposition index in the muscle+liver IR patients (p=0.048), whereas the low-fat diet increased the disposition index in the liver IR patients (p=0.017). Conclusions/interpretation Although both diets improve insulin sensitivity, there are differences based on basal IR phenotypes. Moreover, according to insulinogenic and disposition index data, a low-fat diet might be more beneficial topatients with liver IR, whereas patients with muscle IR and muscle+liver IR might benefit more from a Mediterranean diet.enBeta cell functionDietary interventionInsulin resistanceLow-fat dietMediterranean dietMediterranean dietGlucose-toleranceSkeletal-muscleLife-stylePreventionSensitivityHealthRiskMetabolismSecretionInsulin resistanceOlive oilDiabetes mellitus, type 2Diet, fat-restrictedDiet, mediterraneanFollow-up studiesLiverFatty acids, monounsaturatedPhenotypeMusclesresearch articleopen accessAceite de olivaDiabetes mellitus tipo 2Dieta mediterráneaDieta con restricción de grasasEstudios de seguimientoHígadoResistencia a la insulina10.1007/s00125-015-3776-41432-0428https://link.springer.com/content/pdf/10.1007/s00125-015-3776-4.pdf365804500009