D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats.

Navarro, Juan ADecara, JuanMedina-Vera, DinaTovar, RubénSuarez, JuanPavón, JavierSerrano, AntoniaVida, MargaritaGutierrez-Adan, AlfonsoSanjuan, CarlosBaixeras, ElenaFonseca, Fernando Rodríguez dehttps://www.mdpi.com/2072-6643/12/7/20302023-02-092023-02-092020-07-08Navarro JA, Decara J, Medina-Vera D, Tovar R, Suarez J, Pavón J, et al. D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats. Nutrients. 2020 Jul 8;12(7):2030http://hdl.handle.net/10668/15920To characterize the metabolic actions of D-Pinitol, a dietary inositol, in male Wistar rats, we analyzed its oral pharmacokinetics and its effects on (a) the secretion of hormones regulating metabolism (insulin, glucagon, IGF-1, ghrelin, leptin and adiponectin), (b) insulin signaling in the liver and (c) the expression of glycolytic and neoglucogenesis enzymes. Oral D-Pinitol administration (100 or 500 mg/Kg) resulted in its rapid absorption and distribution to plasma and liver compartments. Its administration reduced insulinemia and HOMA-IR, while maintaining glycaemia thanks to increased glucagon activity. In the liver, D-Pinitol reduced the key glycolytic enzyme pyruvate kinase and decreased the phosphorylation of the enzymes AKT and GSK-3. These observations were associated with an increase in ghrelin concentrations, a known inhibitor of insulin secretion. The profile of D-Pinitol suggests its potential use as a pancreatic protector decreasing insulin secretion through ghrelin upregulation, while sustaining glycaemia through the liver-based mechanisms of glycolysis control.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AKTD-Pinitolghrelininsulininsulin resistanceliverphosphorylationAdministration, OralAnimalsDepression, ChemicalFabaceaeGhrelinGlucagonGlycogenGlycogen Synthase Kinase 3GlycolysisInositolInsulin SecretionLiverMalePhosphorylationProto-Oncogene Proteins c-aktPyruvate KinaseRats, WistarD-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats.research article32650579open accessAdiponectinaFosforilaciónGlucólisisHormonasSecreción de insulinaMetabolismo10.3390/nu120720302072-6643PMC7400942https://www.mdpi.com/2072-6643/12/7/2030/pdf?version=1594216834https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400942/pdf