Díez, Juan JAnda, EmmaSastre, JuliaPérez Corral, BegoñaÁlvarez-Escolá, CristinaManjón, LauraPaja, MiguelSambo, MarcelSantiago Fernández, PiedadBlanco Carrera, ConcepciónGalofré, Juan CNavarro, ElenaZafón, CarlesSanz, EvaOleaga, AmeliaBandrés, OrosiaDonnay, SergioMegía, AnaPicallo, MaríaSánchez Ragnarsson, CeciliaBaena-Nieto, GloriaFernández-García, José CarlosLecumberri, BeatrizSahún de la Vega, ManelRomero-Lluch, Ana RIglesias, Pedro2025-01-072025-01-0720202227-684Xhttps://hdl.handle.net/10668/25118Recent guidelines for the treatment of hypoparathyroidism emphasize the need for long-term disease control, avoiding symptoms and hypocalcaemia. Our aim has been to analyze the prevalence of poor disease control in a national cohort of patients with hypoparathyroidism, as well as to evaluate predictive variables of inadequate disease control. From a nation-wide observational study including a cohort of 1792 patients undergoing total thyroidectomy, we selected 260 subjects [207 women and 53 men, aged (mean ± SD) 47.2±14.8 years] diagnosed with permanent hypoparathyroidism. In every patient demographic data and details on surgical procedure, histopathology, calcium (Ca) metabolism, and therapy with Ca and calcitriol were retrospectively collected. A patient was considered not adequately controlled (NAC) if presented symptoms of hypocalcemia or biochemical data showing low serum Ca levels or high urinary Ca excretion. Two hundred and twenty-one (85.0%) patients were adequately controlled (AC) and 39 (15.0%) were NAC. Comparison between AC and NAC patients did not show any significant difference in demographic, surgical, and pathological features. Rate of hospitalization during follow-up was significantly higher among NAC patients in comparison with AC patients (35.9% vs. 10.9%, P In a nation-wide cohort of 260 subjects with definitive hypoparathyroidism, 15% of them had poor disease control. These patients required higher doses of oral Ca and calcitriol, had higher rate of hospitalization during follow-up and showed lower PTH concentrations in the postoperative period.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Permanent hypoparathyroidismadequacy of controlparathyroid hormone (PTH)thyroidectomyresearch article33224813open access10.21037/gs-20-288PMC7667118https://gs.amegroups.com/article/viewFile/50259/pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC7667118/pdf