Fontserè, SaraInfante-Domínguez, CarmenSuárez-Benjumea, AlejandroSuñer-Poblet, MartaGonzález-Corvillo, CarmenMartín-Gutiérrez, GuillermoBernal, GabrielPachón, JerónimoPachón-Ibáñez, María EugeniaCordero, Elisa2022-11-222022-11-222021-02-22Fontserè S, Infante-Domínguez C, Suárez-Benjumea A, Suñer-Poblet M, González-Corvillo C, Martín-Gutiérrez G, et al. Impact of Treating Asymptomatic Bacteriuria in Kidney Transplant Recipients: A Prospective Cohort Study. Antibiotics. 2021 Feb 22;10(2):218http://hdl.handle.net/10668/4389This study aims to define the epidemiologic, clinical, and microbiological features of asymptomatic bacteriuria (AB) and cystitis in kidney transplantation recipients (KTRs), and to determine the impact of antimicrobial therapy of AB and the risk factors of cystitis. We conducted a prospective observational study of AB and cystitis in KTRs from January to June 2017. One-hundred ninety seven KTRs were included: 175 (88.8%) with AB and 22 (11.2%) with cystitis. The most frequent etiologies were Escherichia coli, Klebsiellapneumoniae, Enterococcusfaecalis, and Pseudomonas aeruginosa. No differences were observed regarding the etiologies, antimicrobial susceptibility patterns, and microbiologic outcomes in AB vs. cystitis. The treatment of AB diminished the microbiological cure and increased the rates of microbiologic relapses and reinfections; in addition, treated AB patients showed a trend of developing symptomatic urinary tract infection in the following six months. The analysis of the data identified the following independent risk factors for cystitis during the six months of follow-up: AB treatment, thymoglobulin induction, previous acute pyelonephritis, and time since transplantation < 1 year. In summary, considering the lack of clinical benefits of treating AB and its impact on cystitis development in the follow-up, we support the recommendation of not screening for or treating AB.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Urinary tract infectionsKidney recipientsAsymptomatic bacteriuriaCystitisProspective observational cohortInfecciones urinariasReceptores de trasplantesTrasplante de riñónInfecciones asintomáticasCistitisEstudio observacionalEstudios de cohortesMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Urinary Tract Infections::BacteriuriaMedical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Lactobacillales::Enterococcaceae::Enterococcus::Enterococcus faecalisMedical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Klebsiella::Klebsiella pneumoniaeMedical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Aerobic Bacteria::Gram-Negative Aerobic Rods and Cocci::Pseudomonadaceae::Pseudomonas::Pseudomonas aeruginosaMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Renal Replacement Therapy::Kidney TransplantationMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up StudiesMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Urinary Tract InfectionsMedical Subject Headings::Diseases::Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Nephritis::Nephritis, Interstitial::PyelonephritisMedical Subject Headings::Diseases::Male Urogenital Diseases::Urologic Diseases::Urinary Bladder Diseases::CystitisMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agentsresearch article33671718open access10.3390/antibiotics100202182079-6382PMC7926960