Martin-Serrano, AngelaMayorga, CristobalinaBarrionuevo, EstherPerez, NataliaRomano, AntoninoMoreno, EstherAriza, AdrianaPerez-Inestrosa, EzequielTorres, Maria JMontañez, Maria I2023-02-082023-02-082019-12-17Martín-Serrano A, Mayorga C, Barrionuevo E, Pérez N, Romano A, Moreno E, et al. Design of an antigenic determinant of cefaclor: Chemical structure-IgE recognition relationship. J Allergy Clin Immunol. 2020 Apr;145(4):1301-1304.e4http://hdl.handle.net/10668/14806Like penicillins, cephalosporins are common antibiotics inducing adverse drug reactions mediated by specific immunologic mechanisms.1 The ‘‘hapten hypothesis’’ states that b-lactams can cause an allergic response only after binding covalently to carrier proteins. In case of cephalosporins, the epitope or antigenic determinant consists of the chemical structure derived after cephalosporin-protein linkage. The lack of knowledge regarding its epitope has hampered the development of standardized in vitro tests to diagnose cephalosporin allergy. Therefore, diagnosis still relies on skin testing and drug provocation tests,2 which, however, are risky, especially for patients with severe reactions. This forces physicians to select alternative b-lactams that, although safe for patients with allergy, may be less effective and show disadvantages related to costs and bacterial resistance.enAdolescentAdultAnti-bacterial agentsCefaclorChildChild, preschoolDrug designDrug hypersensitivityDrug-related side effects and adverse reactionsEpitopesEpitopes, B-LymphocyteFemaleHumansImmunoglobulin EMaleMiddle agedMolecular structureProtein dindingStructure-activity relationshipYoung adultresearch article31821817open accessAdolescenteAdultoAntibacterianosCefaclorDiseño de fármacosEpítoposEpítopos de linfocito BEstructura molecularHipersensibilidad a las drogasRelación estructura-actividad10.1016/j.jaci.2019.11.0361097-6825http://www.jacionline.org/article/S009167491931629X/pdf