Rodríguez-Gómez, IsabelMoliz, Juan NQuesada, AndrésMontoro-Molina, SebastianVargas-Tendero, PabloOsuna, AntonioWangensteen, RosemaryVargas, Félix2023-01-252023-01-252015-12-15http://hdl.handle.net/10668/9667This study assessed the effects of thyroid hormones on the enzymes involved in l-arginine metabolism and the metabolites generated by the different metabolic pathways. Compounds of l-arginine metabolism were measured in the kidney, heart, aorta, and liver of euthyroid, hyperthyroid, and hypothyroid rats after 6 weeks of treatment. Enzymes studied were NOS isoforms (neuronal [nNOS], inducible [iNOS], and endothelial [eNOS]), arginases I and II, ornithine decarboxylase (ODC), ornithine aminotransferase (OAT), and l-arginine decarboxylase (ADC). Metabolites studied were l-arginine, l-citrulline, spermidine, spermine, and l-proline. Kidney heart and aorta levels of eNOS and iNOS were augmented and reduced (P enHyperthyroidismaortaheart kidneyhypothyroidisml-arginine metabolismratAnimalsAortaArginineHyperthyroidismHypothyroidismKidneyLiverMaleMetabolic Networks and PathwaysMyocardiumRats, WistarThyroid Hormonesresearch article26674221open access10.1177/15353702156190421535-3699PMC4950482https://europepmc.org/articles/pmc4950482?pdf=renderhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950482/pdf