Arévalos, VictorOrtega-Paz, LuisFernandez-Rodríguez, DiegoAlfonso Jiménez-Díaz, VíctorRius, Jordi BañerasCampo, GianlucaRodríguez-Santamarta, Miguelde Prado, Armando PérezGómez-Menchero, AntonioDíaz Fernández, José FranciscoScardino, ClaudiaGonzalo, NievesPernigotti, AlbertoAlfonso, FernandoJesús Amat-Santos, IgnacioSilvestro, AntonioIelasi, AlfonsoMaría de la Torre, JoséBastidas, GabrielaGómez-Lara, JosepSabaté, ManelBrugaletta, SalvatoreCV COVID-19 Registry Investigators2023-02-092023-02-092021-07-29http://hdl.handle.net/10668/18274Patients presenting with the coronavirus-2019 disease (COVID-19) may have a high risk of cardiovascular adverse events, including death from cardiovascular causes. The long-term cardiovascular outcomes of these patients are entirely unknown. We aim to perform a registry of patients who have undergone a diagnostic nasopharyngeal swab for SARS-CoV-2 and to determine their long-term cardiovascular outcomes. This is a multicenter, observational, retrospective registry to be conducted at 17 centers in Spain and Italy (ClinicalTrials.gov number: NCT04359927). Consecutive patients older than 18 years, who underwent a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for SARS-CoV2 in the participating institutions, will be included since March 2020, to August 2020. Patients will be classified into two groups, according to the results of the RT-PCR: COVID-19 positive or negative. The primary outcome will be cardiovascular mortality at 1 year. The secondary outcomes will be acute myocardial infarction, stroke, heart failure hospitalization, pulmonary embolism, and serious cardiac arrhythmias, at 1 year. Outcomes will be compared between the two groups. Events will be adjudicated by an independent clinical event committee. The results of this registry will contribute to a better understanding of the long-term cardiovascular implications of the COVID19.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Arrhythmias, CardiacCOVID-19Cardiovascular SystemFemaleHeart FailureHumansItalyMaleMyocardial InfarctionPulmonary EmbolismRegistriesRetrospective StudiesSpainStrokeTime FactorsTreatment Outcomeresearch article34324524open access10.1371/journal.pone.02552631932-6203PMC8320971https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0255263&type=printablehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320971/pdf