Lamberti, NicolaManfredini, FabioNardi, FrancescaBaroni, AndreaPiva, GiovanniCrepaldi, AnnaBasaglia, NinoCasetta, IlariaStraudi, Sofia2023-05-032023-05-032022-03-21Lamberti N, Manfredini F, Nardi F, Baroni A, Piva G, Crepaldi A, et al. Cortical Oxygenation during a Motor Task to Evaluate Recovery in Subacute Stroke Patients: A Study with Near-Infrared Spectroscopy. Neurol Int. 2022 Mar 23;14(2):322-3352035-8385http://hdl.handle.net/10668/21446In subacute stroke patients we studied cortical oxygenation changes by near-infrared spectroscopy (NIRS) during a motor task performed with the hemiparetic arm (15 s of reaching and grasping, 45 s of rest, repeated 6 times). Twenty-three subjects were included at baseline, compared with six healthy subjects, and restudied after 6 weeks of rehabilitation. Motor/premotor cortical changes in oxyhemoglobin detected by NIRS were quantified as the area under the curve (AUC) for the total cortex (TOT-AUC) and for both affected (AFF-AUC) and unaffected hemispheres (UN-AUC). The ratio between AUC and the number of task repetitions performed identified the cortical metabolic cost (CMC) or the oxygenation increase for a single movement. Fugl−Meyer assessment of the upper extremity (FMA-UE) was also performed. At baseline, both total and hemispheric CMC were significantly higher in stroke patients than in healthy subjects and inversely correlated with FMA-UE. After rehabilitation, changes in total-CMC and unaffected-CMC, but not Affected-CMC, were inversely correlated with variations in the FMA-UE score. A value > 5000 a.u. for the ratio baseline TOT-CMC/days since stroke was associated with not reaching the clinically important difference for FMA-UE after rehabilitation. In subacute stroke the CMC, a biomarker assessed by NIRS during a motor task with the hemiparetic arm, may describe cortical time/treatment reorganization and favor patient selection for rehabilitation.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Cortical activityExercise testingExercise therapyMotor taskNear-infrared spectroscopyRehabilitationStrokeOxyhemoglobinsArmArea Under CurveHealthy VolunteersPatient selectionSpectroscopy, near-infraredStrokeBiomarkersUnited nationsCortical Oxygenation during a Motor Task to Evaluate Recovery in Subacute Stroke Patients: A Study with Near-Infrared Spectroscopy.Research article35466207open accessAccidente cerebrovascularBiomarcadoresBrazoEspectroscopía infrarroja cortaNaciones unidasOxihemoglobinasSelección de pacienteVoluntarios sanosÁrea bajo la curva10.3390/neurolint14020026PMC9036242https://www.mdpi.com/2035-8377/14/2/26/pdf?version=1648006195https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036242/pdf