Pertesi, MaroulioVallee, MaximeWei, XiaomuRevuelta, Maria VGalia, PerrineDemangel, DelphineOliver, JavierFoll, MatthieuChen, SiweiPerrial, EmelineGarderet, LaurentCorre, JillLeleu, XavierBoyle, Eileen MDecaux, OlivierRodon, PhilippeKolb, BrigitteSlama, BorhaneMineur, PhilippeVoog, EricLe Bris, CatherineFontan, JeanMaigre, MichelBeaumont, MarieAzais, IsabelleSobol, HagayVignon, MargueriteRoyer, BrunoPerrot, AuroreFuzibet, Jean-GabrielDorvaux, VEroniqueAnglaret, BrunoCony-Makhoul, PascaleBerthou, ChristianDesquesnes, FlorencePegourie, BrigitteLeyvraz, SergeMosser, LaurentFrenkiel, NicoleAugeul-Meunier, KarineLeduc, IsabelleLeyronnas, CecileVoillat, LaurentCasassus, PhilippeMathiot, ClaireCheron, NathaliePaubelle, EtienneMoreau, PhilippeBignon, Yves-JeanJoly, BertrandBourquard, PascalCaillot, DenisNaman, HerveRigaudeau, SophieMarit, GeraldMacro, MargaretLambrecht, IsabelleCliquennois, ManuelVincent, LaureHelias, PhilippeAvet-Loiseau, HerveMoreno, VictorReis, Rui ManuelVarkonyi, JuditKruszewski, MarcinVangsted, Annette JuulJurczyszyn, ArturZaucha, Jan MaciejSainz, JuanKrawczyk-Kulis, MalgorzataWątek, MarzenaPelosini, MatteoIskierka-Jażdżewska, ElzbietaGrząśko, NorbertMartinez-Lopez, JoaquinJerez, AndresCampa, DanieleBuda, GabrieleLesueur, FabienneDudziński, MarekGarcia-Sanz, RamonNagler, ArnonRymko, MarcinJamroziak, KrzysztofButrym, AleksandraCanzian, FedericoObazee, OfureNilsson, BjörnKlein, Robert JLipkin, Steven MMcKay, James DDumontet, Charles2023-01-252023-01-252019-02-08Pertesi M, Vallée M, Wei X, Revuelta MV, Galia P, Demangel D, et al. Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma. Leukemia. 2019 Sep;33(9):2324-2330http://hdl.handle.net/10668/13806Multiple myeloma (MM) is the third most common hematological malignancy, after Non-Hodgkin Lymphoma and Leukemia. MM is generally preceded by Monoclonal Gammopathy of Undetermined Significance (MGUS), and epidemiological studies have identified older age, male gender, family history, and MGUS as risk factors for developing MM.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/MielomaExomaFemaleGermline mutationExomeExosome multienzyme ribonuclease complexFemaleGenetic predisposition to diseaseGerm-line mutationHumansMultiple myelomaPedigreeExome sequencingresearch article30967618open accessComplejo multienzimático de ribonucleasas del exosomaExomaFemeninoHumanosLinajeMieloma múltipleMutación de línea germinalPredisposición genética a la enfermedadSecuenciación del exoma10.1038/s41375-019-0452-61476-5551PMC6756025https://www.nature.com/articles/s41375-019-0452-6.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756025/pdf