Cӑtoi, Adriana FlorinelaCorina, AndreeaKatsiki, NikiVodnar, Dan CristianAndreicut, Andra DianaStoian, Anca PanteaRizzo, ManfrediPerez-Martinez, Pablo2023-02-082023-02-082020-03-06Cӑtoi AF, Corina A, Katsiki N, Vodnar DC, Andreicuț AD, Stoian AP, Rizzo M, Pérez-Martínez P. Gut microbiota and aging-A focus on centenarians. Biochim Biophys Acta Mol Basis Dis. 2020 Jul 1;1866(7):165765http://hdl.handle.net/10668/15237Gut microbiota (GM) is a dynamic organ throughout the lifespan. Aging is a complex process that comprises a plethora of mechanisms such as senescence, immunosenescence and inflammaging, representing important pathways of age-related diseases. GM structure could both influence and be influenced by aging occurring changes within the host. A unique category of long living individuals exists, namely centenarians that have the outstanding capacity to adapt to various challenges. Longevity seems to be associated with certain GM which, among other factors, might render individuals more resistant to age-related diseases and subsequently to long living. Diet, prebiotics, probiotics and synbiotics may contribute to longevity through GM modulating. Currently, the exact mechanisms of the association between GM and the host in relation with extended lifespan remain unknown and should be further investigated.enAgingCentenariansGut microbiotaPrebioticsProbioticsSynbioticsAged, 80 and overAgingGastrointestinal MicrobiomeHumansLongevityPrebioticsProbioticsSynbioticsresearch article32169505open access10.1016/j.bbadis.2020.1657651879-260Xhttps://doi.org/10.1016/j.bbadis.2020.165765