García-Argüello, Segundo FranciscoLopez-Lorenzo, BeatrizCornelissen, BartSmith, Graham2022-09-272022-09-272020-08-06García-Argüello SF, Lopez-Lorenzo B, Cornelissen B, Smith G. Development of [18F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis. Cancers. 2020 Aug 6;12(8):2191http://hdl.handle.net/10668/4148Insufficient apoptosis is a recognised hallmark of cancer. A strategy to quantitatively measure apoptosis in vivo would be of immense value in both drug discovery and routine patient management. The first irreversible step in the apoptosis cascade is activation of the "executioner" caspase-3 enzyme to commence cleavage of key structural proteins. One strategy to measure caspase-3 activity is Positron Emission Tomography using isatin-5-sulfonamide radiotracers. One such radiotracer is [18F]ICMT-11, which has progressed to clinical application. This review summarises the design and development process for [18F]ICMT-11, suggesting potential avenues for further innovation.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Positron emission tomographyApoptosisCaspase-3[18F]ICMT-11PyrimidoindoloneMichael acceptorNeoplasmsIsatinTomografía de emisión de positronesCaspasa-3NeoplasiasIsatinaMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Cysteine Proteases::Cysteine Endopeptidases::Caspases::Caspases, Effector::Caspase 3Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Indoles::IsatinMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Radioisotope::Radionuclide Imaging::Tomography, Emission-Computed::Positron-Emission TomographyMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::NADH, NADPH Oxidoreductases::Apoptosis Inducing FactorMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::SulfonamidesMedical Subject Headings::Diseases::NeoplasmsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Drug DiscoveryMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humansreview article32781531Acceso abierto10.3390/cancers120821912072-6694PMC7465189