Fernández-Cidón, BárbaraCandás-Estébanez, BeatrizGil-Serret, MiriamAmigó, NúriaCorbella, EmiliRodríguez-Sánchez, M. ÁngelesPadró-Miquel, AriadnaBrotons, CarlosHernández-Mijares, AntonioCalmarza, PilarJarauta, EstibalizBrea, Angel J.Mauri, MartaGuijarro, CarlosVila, ÀlexValdivielso, PedroCorbella, XavierPintó, Xavier2023-01-162023-01-162021-03-29Fernández-Cidón B, Candás-Estébanez B, Gil-Serret M, Amigó N, Corbella E, Rodríguez-Sánchez MÁ, et al. Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study. J Clin Med. 2021 Mar 29;10(7):1379http://hdl.handle.net/10668/4588Some lipoprotein disorders related to the residual risk of premature cardiovascular disease (PCVD) are not detected by the conventional lipid profile. In this case-control study, the predictive power of PCVD of serum sdLDL-C, measured using a lipoprotein precipitation method, and of the physicochemical properties of serum lipoproteins, analyzed by nuclear magnetic resonance (NMR) techniques, were evaluated. We studied a group of patients with a first PCVD event (n = 125) and a group of control subjects (n = 190). Conventional lipid profile, the size and number of Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL) particles, and the number of particles of their subclasses (large, medium, and small) were measured. Compared to controls, PCVD patients had lower concentrations of all LDL particles, and smaller and larger diameter of LDL and HDL particles, respectively. PCVD patients also showed higher concentrations of small dense LDL-cholesterol (sdLDL), and triglycerides (Tg) in LDL and HDL particles (HDL-Tg), and higher concentrations of large VLDL particles. Multivariate logistic regression showed that sdLDL-C, HDL-Tg, and large concentrations of LDL particles were the most powerful predictors of PCVD. A strong relationship was observed between increased HDL-Tg concentrations and PCVD. This study demonstrates that beyond the conventional lipid profile, PCVD patients have other atherogenic lipoprotein alterations that are detected by magnetic resonance imaging (MRI) analysis.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/NMR analysis of lipoproteinsLipid profilePremature cardiovascular diseaseResidual cardiovascular riskSmall dense LDLLipoprotein particle numberLipoprotein precipitationTriglyceridesAtherosclerosisLípidosEnfermedades cardiovascularesFactores de riesgo de enfermedad cardiacaLDL-colesterolLipoproteínasTriglycéridosAterosclerosisMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, LDL::Cholesterol, LDLMedical Subject Headings::Diseases::Cardiovascular DiseasesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control StudiesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic ModelsMedical Subject Headings::Chemicals and Drugs::Lipids::Glycerides::TriglyceridesMedical Subject Headings::Chemicals and Drugs::Lipids::LipoproteinsMedical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, VLDLMedical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::ArteriosclerosisMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imagingresearch article33805580open access10.3390/jcm100713792077-0383PMC8037702