Grothe, Michel JMoscoso, AlexisSilva-Rodriguez, JesusLange, CatharinaNho, KwangsikSaykin, Andrew JNelson, Peter TSchöll, MichaelBuchert, RalphTeipel, Stefan2023-05-032023-05-032022-04-13Grothe MJ, Moscoso A, Silva-Rodríguez J, Lange C, Nho K, Saykin AJ, et al. Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC. Alzheimers Dement. 2023 Apr;19(4):1234-1244.http://hdl.handle.net/10668/20285Limbic age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is common in advanced age and can underlie a clinical presentation mimicking Alzheimer's disease (AD). We studied whether an autopsy-derived fluorodeoxyglucose positron emission tomography (FDG-PET) signature of LATE-NC provides clinical utility for differential diagnosis of amnestic dementia patients. Ante mortem FDG-PET patterns from autopsy-confirmed LATE-NC (N = 7) and AD (N = 23) patients were used to stratify an independent cohort of clinically diagnosed AD dementia patients (N = 242) based on individual FDG-PET profiles. Autopsy-confirmed LATE-NC and AD groups showed markedly distinct temporo-limbic and temporo-parietal FDG-PET patterns, respectively. Clinically diagnosed AD dementia patients showing a LATE-NC-like FDG-PET pattern (N = 25, 10%) were significantly older, showed less abnormal AD biomarker levels, lower APOE ε4, and higher TMEM106B risk allele load. Clinically, they exhibited a more memory-predominant profile and a generally slower disease course. An autopsy-derived temporo-limbic FDG-PET signature identifies older amnestic patients whose clinical, genetic, and molecular biomarker features are consistent with underlying LATE-NC.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/TDP-43TMEM106Bamyloidapolipoprotein Eautopsyfluorodeoxyglucose positron emission tomographyhippocampal sclerosislimbic age-related TDP-43 encephalopathytaulimbic-predominant age-related TDP-43 encephalopathyDiagnosis, DifferentialFluorodeoxyglucose F18Alzheimer DiseasePositron-Emission TomographyDNA-Binding ProteinsApolipoproteins Eresearch article35971593open accessMascotasPacientesAutopsiaDemenciaBiomarcadoresAlelosApolipoproteínas EEncefalopatíasMemoriaEnfermedad de Alzheimer10.1002/alz.127631552-5279PMC9929029https://doi.org/10.1002/alz.12763https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9929029/pdf