Treatment Discontinuation Impact on Long-Term (10-Year) Weight Gain and Lipid Metabolism in First-Episode Psychosis: Results From the PAFIP-10 Cohort.

Vazquez-Bourgon, JavierMayoral-van Son, JaquelineGomez-Revuelta, MarcosJuncal-Ruiz, MariaOrtiz-Garcia de la Foz, VíctorTordesillas-Gutierrez, DianaAyesa-Arriola, RosaBioque, MiquelCrespo-Facorro, Benedicto2023-02-092023-02-092020-08-25Vázquez-Bourgon J, Mayoral-van Son J, Gómez-Revuelta M, Juncal-Ruiz M, Ortiz-García de la Foz V, Tordesillas-Gutiérrez D, et al. Treatment Discontinuation Impact on Long-Term (10-Year) Weight Gain and Lipid Metabolism in First-Episode Psychosis: Results From the PAFIP-10 Cohort. Int J Neuropsychopharmacol. 2021 Jan 20;24(1):1-7.http://hdl.handle.net/10668/16148Patients with a first episode of psychosis (FEP) are at higher risk of gaining weight and presenting metabolic disturbances, partly related to antipsychotic exposure. Previous studies suggest that treatment discontinuation might have a positive impact on weight in schizophrenia. The aim of this study was to evaluate the effect of treatment discontinuation on weight and metabolic changes in a FEP cohort. A total of 209 FEP patients and 57 healthy controls were evaluated at study entry and prospectively at 10-year follow-up. Anthropometric measures and, clinical, metabolic, and sociodemographic data were collected. Patients discontinuing antipsychotic treatment presented a significantly lower increase in weight and better metabolic parameter results than those still on antipsychotic treatment at 10-year follow-up. Treatment discontinuation had a positive effect on the weight and metabolic changes observed in FEP patients; however, this effect was not sufficient to reaching a complete reversal to normal levels.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/Treatment discontinuationlipid metabolismmedication-naïvesecond-generation antipsychoticweight gainAdultAntipsychotic AgentsFemaleHumansLipid MetabolismLongitudinal StudiesMalePsychotic DisordersTime FactorsWeight GainYoung AdultTreatment Discontinuation Impact on Long-Term (10-Year) Weight Gain and Lipid Metabolism in First-Episode Psychosis: Results From the PAFIP-10 Cohort.research article32840607open accessTerapéuticaPolitetrafluoroetilenoPacientesAntipsicóticosDihidrotaquisterolTrastornos PsicóticosRiesgoEsquizofrenia10.1093/ijnp/pyaa0661469-5111PMC7816683https://academic.oup.com/ijnp/article-pdf/24/1/1/35927250/pyaa066.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816683/pdf