Jiménez, DavidBikdeli, BehnoodBarrios, DeisyMorillo, RaquelNieto, RosaGuerassimova, InaMuriel, AlfonsoJara-Palomares, LuisMoores, LisaTapson, VictorYusen, Roger DMonreal, ManuelRIETE investigators2023-01-252023-01-252018-05-10http://hdl.handle.net/10668/12419The impact of adherence to published guidelines on the outcomes of patients with acute pulmonary embolism (PE) has not been well defined by previous studies.In this prospective cohort study of patients admitted to a respiratory department (n=2096), we evaluated whether patients with PE had better outcomes if they were acutely managed according to international guidelines. Outcomes consisted of all-cause mortality, PE-related mortality, recurrent venous thromboembolism (VTE) and major bleeding events during the first month of follow-up after diagnosis.Overall, 408 patients (19% (95% CI 18-21%)) did not receive guideline-adherent PE management. Patients receiving non-adherent management were significantly more likely to experience all-cause mortality (adjusted odds ratio (OR) 2.39 (95% CI 1.57-3.61) or PE-related mortality (adjusted OR 5.02 (95% CI 2.42-10.42); penAgedAnticoagulantsCohort StudiesFemaleFibrinolytic AgentsGuideline AdherenceHemorrhageHumansMaleMiddle AgedOutcome and Process Assessment, Health CarePatient Care ManagementPractice Guidelines as TopicProspective StudiesPulmonary EmbolismQuality ImprovementRecurrenceRespiratory Care UnitsSpainVena Cava FiltersVenous Thromboembolismresearch article29724918open access10.1183/13993003.00445-20181399-3003https://erj.ersjournals.com/content/erj/51/5/1800445.full.pdf