Fernández-García, José CarlosLópez-Medina, José AntonioBerchid-Debdi, MohammedTinahones Madueño, Francisco José2013-02-072013-02-072012-09Fernández-García JC, López-Medina JA, Berchid-Debdi M, Tinahones Madueño FJ. Resistance to thyroid hormone and down syndrome: coincidental association or genetic linkage? Thyroid. 2012; 22(9):973-9741050-7256http://hdl.handle.net/10668/757Carta al DirectorWe report the first case of RTH and DS. Although this congruence could be coincidental, we cannot exclude a possible linkage between both syndromes.esSíndrome de DownSíndrome de Resistencia a Hormonas TiroideasTriyodotironinaTiroglobulinaYoduro PeroxidasaTirotropinaTrastornos PsicomotoresCromosomas Humanos Par 21Cromosomas Humanos Par 3Resistance to thyroid hormoneDown syndromeTRβ genegoitergenetic linkageMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Diseases::Nervous System Diseases::Neurologic Manifestations::Neurobehavioral Manifestations::Intellectual Disability::Down SyndromeMedical Subject Headings::Diseases::Endocrine System Diseases::Thyroid Diseases::Hyperthyroxinemia::Thyroid Hormone Resistance SyndromeMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Thyroid Hormones::Thyronines::TriiodothyronineMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Globulins::ThyroglobulinMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Peroxidases::Iodide PeroxidaseMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, AnteriorMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Neurobehavioral Manifestations::Psychomotor DisordersMedical Subject Headings::Anatomy::Cells::Cellular Structures::Chromosomes::Chromosomes, Mammalian::Chromosomes, Human::Chromosomes, Human, 21-22 and YMedical Subject Headings::Anatomy::Cells::Cellular Structures::Chromosomes::Chromosomes, Mammalian::Chromosomes, Human::Chromosomes, Human, 1-3::Chromosomes, Human, Pair 3Medical Subject Headings::Named Groups::Persons::Age Groups::Child::Child, PreschoolMedical Subject Headings::Check Tags::Maleletter22822713open access10.1089/thy.2011.03161557-9077