Perez-Martinez, PabloAlcala-Diaz, Juan FKabagambe, Edmon KGarcia-Rios, AntonioTsai, Michael YDelgado-Lista, JavierKolovou, GenovefaStraka, Robert JGomez-Delgado, FranciscoHopkins, Paul NMarin, CarmenBorecki, IngridYubero-Serrano, Elena MHixson, James ECamargo, AntonioProvince, Michael ALopez-Moreno, JavierRodriguez-Cantalejo, FernandoTinahones, Francisco JMikhailidis, Dimitri PPerez-Jimenez, FranciscoArnett, Donna KOrdovas, Jose MLopez-Miranda, Jose2023-01-252023-01-252016-05-25Perez-Martinez P, Alcala-Diaz JF, Kabagambe EK, Garcia-Rios A, Tsai MY, Delgado-Lista J, et al. Assessment of postprandial triglycerides in clinical practice: Validation in a general population and coronary heart disease patients. J Clin Lipidol. 2016 Sep-Oct;10(5):1163-711933-2874http://hdl.handle.net/10668/10481Previous studies have suggested that for clinical purposes, subjects with fasting triglycerides (TGs) between 89-180 mg/dl (1-2 mmol/l) would benefit from postprandial TGs testing. To determine the postprandial TG response in 2 independent studies and validate who should benefit diagnostically from an oral-fat tolerance test (OFTT) in clinical practice. A population of 1002 patients with coronary heart disease (CHD) from the CORDIOPREV clinical trial and 1115 white US subjects from the GOLDN study underwent OFTTs. Subjects were classified into 3 groups according to fasting cut points of TGs to predict the usefulness of OFTT: (1) TG  180 mg/dl (>2 mmol/l). Postprandial TG concentration at any point > 220 mg/dl (>2.5 mmol/l) has been pre-established as an undesirable postprandial response. Of the total, 49% patients with CHD and 42% from the general population showed an undesirable response after the OFTT. The prevalence of undesirable postprandial TG in the CORDIOPREV clinical trial was 12.8, 50.3, and 89.7%, in group 1, 2, and 3, respectively (P  These two studies validate the predictive values reported in a previous consensus. Moreover, the findings of the CORDIOPREV and GOLDN studies show that an OFTT is useful to identify postprandial hyperlipidemia in subjects with fasting TG between 1-2 mmol/l (89-180 mg/dL), because approximately half of them have hidden postprandial hyperlipidemia, which may influence treatment. An OFTT does not provide additional information regarding postprandial hyperlipidemia in subjects with low TG (2 mmol/l, >180 mg/dl).enCORDIOPREV studyCoronary heart diseaseGOLDN studyOral-fat tolerance testPostprandial lipemiaTriglyceridesAdultAge FactorsAgedCoronary Artery DiseaseDietary FatsFemaleHumansHyperlipidemiasLogistic ModelsMaleMiddle AgedOdds RatioPostprandial PeriodPrevalenceTriglyceridesresearch article27678433open accessEnfermedad de la arteria coronariaFactores de edadGrasas de la dietaHiperlipidemiasOportunidad relativaTrigliceridos10.1016/j.jacl.2016.05.009PMC7025632https://europepmc.org/articles/pmc7025632?pdf=renderhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025632/pdf