Guerrero-Hue, MelaniaRayego-Mateos, SandraVázquez-Carballo, CristinaPalomino-Antolín, AlejandraGarcía-Caballero, CristinaOpazo-Rios, LucasMorgado-Pascual, José LuisHerencia, CarmenMas, SebastiánOrtiz, AlbertoRubio-Navarro, AlfonsoEgea, JavierVillalba, José ManuelEgido, JesúsMoreno, Juan Antonio2022-05-172022-05-172020-12-31Guerrero-Hue M, Rayego-Mateos S, Vázquez-Carballo C, Palomino-Antolín A, García-Caballero C, Opazo-Rios L, et al. Protective Role of Nrf2 in Renal Disease. Antioxidants. 2020 Dec 31;10(1):39.http://hdl.handle.net/10668/3634Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is characterized by increased oxidative stress and chronic inflammation. However, therapies to slow or prevent CKD progression remain an unmet need. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that plays a key role in protection against oxidative stress and regulation of the inflammatory response. Consequently, the use of compounds targeting Nrf2 has generated growing interest for nephrologists. Pre-clinical and clinical studies have demonstrated that Nrf2-inducing strategies prevent CKD progression and protect from acute kidney injury (AKI). In this article, we review current knowledge on the protective mechanisms mediated by Nrf2 against kidney injury, novel therapeutic strategies to induce Nrf2 activation, and the status of ongoing clinical trials targeting Nrf2 in renal diseases.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Nrf2Renal diseaseAcute kidney injuryOxidative stressInflammatory responseFactor 1 relacionado con NF-E2Enfermedades renalesLesión renal agudaEstrés oxidativoInflamaciónMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Basic-Leucine Zipper Transcription Factors::NF-E2-Related Factor 2Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Cause of DeathMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative StressMedical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Renal Insufficiency, ChronicMedical Subject Headings::Anatomy::Urogenital System::Urinary Tract::KidneyMedical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Acute Kidney InjuryMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammationresearch article33396350Acceso abierto10.3390/antiox100100392076-3921PMC7824104