de Llano, Luis PérezCosío, Borja GIglesias, Amandade Las Cuevas, NatividadSoler-Cataluña, Juan JoseIzquierdo, Jose LuisLópez-Campos, Jose LuisCalero, CarmenPlaza, VicenteMiravitlles, MarcTorrego, AlfonsMartinez-Moragon, EvaSoriano, Joan BViña, Antolin LopezBobolea, Irina2023-01-252023-01-252018-02-12http://hdl.handle.net/10668/12184The asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a clinical condition that combines features of those two diseases, and that is difficult to define due to the lack of understanding of the underlying mechanisms. Determining systemic mediators may help clarify the nature of inflammation in patients with ACO. We aimed at investigating the role and interaction of common markers of systemic inflammation (IL-6, IL-8, and tumor necrosis factor-α), Th2-related markers (periostin, IL-5, and IL-13), and IL-17 in asthma, COPD, and ACO. This is a cross-sectional study of patients aged ≥40 years with a post-bronchodilator forced expiratory volume in the first second/forced vital capacity 10 pack-years in a patient with a previous diagnosis of asthma or by the presence of eosinophilia in a patient with a previous diagnosis of COPD. Clinical, functional, and inflammatory parameters were compared between categories using discriminant and network analysis. In total, 109 ACO, 89 COPD, and 94 asthma patients were included. Serum levels (median [interquartile range]) of IL-5 were higher in asthma patients than in COPD patients (2.09 [0.61-3.57] vs 1.11 [0.12-2.42] pg/mL, respectively; p=0.03), and IL-8 levels (median [interquartile range]) were higher in COPD patients than in asthma patients (9.45 [6.61-13.12] vs 7.03 [4.69-10.44] pg/mL, respectively; p Asthma and COPD are two different inflammatory conditions that may overlap in some patients, leading to a mixed inflammatory pattern. IL-13 could be central to the regulation of inflammation in these conditions.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/COPD mechanismsIL-13asthma mechanismsinflammatory cytokinesnetwork analysisoverlapAdultAgedAsthmaBiomarkersCell Adhesion MoleculesCross-Sectional StudiesDiscriminant AnalysisFemaleForced Expiratory VolumeHumansInflammation MediatorsInterleukin-13Interleukin-17Interleukin-5Interleukin-6Interleukin-8LungMaleMiddle AgedNeural Networks, ComputerPrognosisPulmonary Disease, Chronic ObstructiveSpainTh2 CellsTumor Necrosis Factor-alphaVital Capacityresearch article29483774open access10.2147/COPD.S1536941178-2005PMC5813946https://www.dovepress.com/getfile.php?fileID=40504https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813946/pdf