Martínez-García, FernandoMansego, María L.Rojo-Martínez, GemmaDe Marco-Solar, GriseldaMorcillo, SonsolesSoriguer, FedericoRedón, JosepPineda Alonso, MonicaMartín-Escudero, Juan C.Cooper, Richard S.Chaves, Felipe J.2014-02-142014-02-142013-11-23Martínez-García F, Mansego ML, Rojo-Martínez G, De Marco-Solar G, Morcillo S, Soriguer F, et al. Impact of obesity-related genes in Spanish population. BMC Genet. 2013; 14:111http://hdl.handle.net/10668/1502Journal Article; Research Support, Non-U.S. Gov't;Background: The objective was to investigate the association between BMI and single nucleotide polymorphisms previously identified of obesity-related genes in two Spanish populations. Forty SNPs in 23 obesity-related genes were evaluated in a rural population characterized by a high prevalence of obesity (869 subjects, mean age 46 yr, 62% women, 36% obese) and in an urban population (1425 subjects, mean age 54 yr, 50% women, 19% obese). Genotyping was assessed by using SNPlex and PLINK for the association analysis. Results: Polymorphisms of the FTO were significantly associated with BMI, in the rural population (beta 0.87, p-value <0.001). None of the other SNPs showed significant association after Bonferroni correction in the two populations or in the pooled analysis. A weighted genetic risk score (wGRS) was constructed using the risk alleles of the Tag-SNPs with a positive Beta parameter in both populations. From the first to the fifth quintile of the score, the BMI increased 0.45 kg/m2 in Hortega and 2.0 kg/m2 in Pizarra. Overall, the obesity predictive value was low (less than 1%). Conclusion: The risk associated with polymorphisms is low and the overall effect on BMI or obesity prediction is minimal. A weighted genetic risk score based on genes mainly acting through central nervous system mechanisms was associated with BMI but it yields minimal clinical prediction for the obesity risk in the general population.enObesityGeneticsFTO geneGenetic scoreEspañaObesidadGenéticaÍndice de masa corporalEstudio de asociación del genoma completoPolimorfismo de nucleótido simpleAndalucíaMedical Subject Headings::Geographicals::Geographic Locations::Europe::SpainMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Named Groups::Persons::Age Groups::AdultMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::ObesityMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Biometry::Anthropometry::Body Mass IndexMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Genome-Wide Association StudyMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotideresearch article24267414open access10.1186/1471-2156-14-1111471-2156