Frias, MarioRivero-Juarez, AntonioTellez, FranciscoPerez-Perez, MonserratCamacho, AngelaMachuca, IsabelLorenzo-Moncada, SandraLopez-Lopez, PedroRivero, Antonio2023-01-252023-01-252017-04-21Frias M, Rivero-Juarez A, Tellez F, Perez-Perez M, Camacho A, Machuca I, et al. Grupo de Estudio de Hepatitis Virales (HEPAVIR) of the Sociedad Andaluza de Enfermedades Infecciosas (SAEI). Spontaneous clearance of chronic hepatitis C is rare in HIV-infected patients after effective use of combination antiretroviral therapy. PLoS One. 2017 May 4;12(5):e0177141http://hdl.handle.net/10668/11170To evaluate the rate of spontaneous resolution of chronic hepatitis C (CHC) infection in a cohort of HIV-infected patients. A retrospective analysis of 509 HIV-infected patients with chronic HCV infection was performed at two reference hospitals in Andalusia. The main variable of the study was spontaneous clearance of CHC, defined as a negative HCV RNA result after at least two previous quantitative measurements of HCV RNA separated by a minimum of 12 months. Of 509 patients, 3 (0.59%; 95% CI: 0.15%-1.6%) experienced spontaneous clearance of CHC. After combination antiretroviral therapy (cART) initiation, two of three cases experienced an increased CD4+ count, coinciding with HCV viral clearance. All patients were IL28B CC carriers, 2 were co-infected with HCV genotype 3 (the HCV genotype of the remaining patient was not available). Spontaneous clearance of CHC is a rare event in the context of HIV/HCV co-infected patients and may be associated with the effective use of cART and thus HIV suppression.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AdultAnti-HIV AgentsFemaleHIV InfectionsHepatitis C, ChronicHumansMaleRemission InductionRetrospective StudiesYoung Adultresearch article28472191open accessFarmacos anti-VIHHepatitis C cronicaInduccion de remisionInfecciones por VIHEstudios retrospectivosAdulto joven10.1371/journal.pone.01771411932-6203PMC5417670https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0177141&type=printablehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417670/pdf