Moral-Martos, AmadoraGuerrero-Fernández, JulioGomez-Balaguer, MarcelinoRica Echevarria, ItxasoCampos-Martorell, AriadnaChueca-Guindulain, Maria JesusGarcia Garcia, EmilioHoyos-Gurrea, RaulLopez de Lara, DiegoLopez-Siguero, Juan PedroMartos Tello, Jose MariaMora Palma, CristinaRiaño Galan, IsolinaYeste Fernandez, Diego2023-05-032023-05-032022-02-18Moral-Martos A, Guerrero-Fernández J, Gómez-Balaguer M, Rica Echevarría I, Campos-Martorell A, Chueca-Guindulain MJ, García García E, Hoyos-Gurrea R, López de Lara D, López-Siguero JP, Martos Tello JM, Mora Palma C, Riaño Galán I, Yeste Fernández D. Clinical practice guidelines for transsexual, transgender and gender diverse minors. An Pediatr (Engl Ed). 2022 Apr;96(4):349.e1-349.e11http://hdl.handle.net/10668/21922Some people, including minors, have a gender identity that does not correspond to the sex assigned at birth. They are known as trans* people, which is an umbrella term that encompasses transgender, transsexual, and other identities not conforming to the assigned gender. Healthcare units for trans* minors require multidisciplinary working, undertaken by personnel expert in gender identity, enabling, when requested, interventions for the minor and their social-familial environment, in an individualized and flexible way during the gender affirmation path. This service model also includes hormonal treatments tailored as much as possible to the individual's needs, beyond the dichotomic goals of a traditional binary model. This guide addresses the general aspects of professional care of trans* minors and presents the current evidence-based protocol of hormonal treatments for trans* and non-binary adolescents. In addition, it details key aspects related to expected body changes and their possible side effects, as well as prior counselling about fertility preservation.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Bloqueo puberalDisforia de géneroFertilidadFertilityGender dysphoriaGender identityGender incongruenceGender-affirming hormonal treatmentHormone cross therapyIdentidad de géneroIncongruencia de géneroNo binarioNon-binaryPubertal blockadePuberty suppressionSupresión de la pubertadTerapia hormonal cruzadaTerapia hormonal de afirmación de géneroTransgenderTransgéneroAdolescentFemaleGender DysphoriaGender IdentityHumansMaleMinorsPractice Guidelines as TopicTransgender PersonsTranssexualismresearch article35534418open accessAdolescentDelivery of Health CareEnvironmentGender Identity10.1016/j.anpede.2022.02.0022341-2879https://doi.org/10.1016/j.anpede.2022.02.002