van Straalen, Kelsey RTzellos, ThrasyvoulosGuillem, PhillipeBenhadou, FaridaCuenca-Barrales, CarlosDaxhelet, MathildeDaoud, MathieuEfthymiou, OuraniaGiamarellos-Bourboulis, Evangelos JJemec, Gregor B EKatoulis, Alexandros CKoenig, AnkeLazaridou, ElizabethMarzano, Angelo VMatusiak, ŁucasMolina-Leyva, AlejandroMoltrasio, ChiaraPinter, AndreasPotenza, ConcettaRomaní, JorgeSaunte, Ditte MSkroza, NevenaStergianou, DimitraSzepietowski, JacekTrigoni, AnastasiaVilarrasa, Evavan der Zee, Hessel H2023-02-092023-02-092021-01-20http://hdl.handle.net/10668/17028Tetracyclines and clindamycin plus rifampicin combination therapy are both considered first-line therapy in current hidradenitis suppurativa guidelines. However, evidence for their efficacy is drawn from small studies, often without validated outcomes. To assess the 12-week efficacy of oral tetracyclines and a combination of clindamycin and rifampicin. A prospective, international cohort study performed between October 2018 and August 2019. In total, 63.6% of the included 283 patients received oral tetracyclines, and 36.4% were treated with clindamycin and rifampicin. Both groups showed a significant decrease in International Hidradenitis Suppurativa Severity Score System from baseline (both P  Cohort study. Respectively, 23.9% and 19.4% of patients had to be excluded from the HiSCR analysis for the tetracycline and combination therapy group because of a low abscess and nodule count at baseline. This study shows significant efficacy of both tetracycline treatment and clindamycin and rifampicin combination therapy after 12 weeks in patients with hidradenitis suppurativa. No significant differences in efficacy were observed between the 2 treatments, regardless of disease severity.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/acne inversaantibioticsclindamycindoxycyclineefficacyguidelineminocyclineoutcomerifampicintetracyclinetherapytreatmentAdultClindamycinCohort StudiesDrug CombinationsEuropeFemaleHidradenitis SuppurativaHumansMaleMiddle AgedProspective StudiesRifampinTetracyclinesTreatment Outcomeresearch article33484766open access10.1016/j.jaad.2020.12.0891097-6787http://www.jaad.org/article/S0190962221001766/pdf