Marhuenda-Muñoz, MaríaDomínguez-López, InésLaveriano-Santos, Emily PParilli-Moser, IsabellaRazquin, CristinaRuiz-Canela, MiguelBasterra-Gortari, Francisco JavierCorella, DoloresSalas-Salvadó, JordiFitó, MontserratLapetra, JoséArós, FernandoFiol, MiquelSerra-Majem, LluisPintó, XavierGómez-Gracia, EnriqueRos, EmilioEstruch, RamonLamuela-Raventós, Rosa M2023-05-032023-05-032022-08-082076-3921http://hdl.handle.net/10668/20787The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23−0.64]; penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Mediterranean dietPREDIMED studybioactive compoundscardiovascularliquid chromatographymass spectrometryphytochemicalsurinary microbial phenolic metabolitesresearch article36009259open access10.3390/antiox11081540PMC9405292https://www.mdpi.com/2076-3921/11/8/1540/pdf?version=1660188009https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405292/pdf