Garces, Maria FernandaBuell-Acosta, Julieth DanielaRodriguez-Navarro, Haiver AntonioPulido-Sanchez, EstefaniaRincon-Ramirez, Juan JoseMoreno-Ordoñez, Diana CarolinaFranco-Vega, RobertoRoncancio-Muñoz, Jhoan SebastianBurgos-Cardenas, Alvaro JavierLacunza, EzequielCastaño, Justo P.Dieguez, CarlosNogueiras, RubenSanchez, ElizabethCaminos, Jorge Eduardo2023-02-092023-02-092020-09-29Garcés MF, Buell-Acosta JD, Rodríguez-Navarro HA, Pulido-Sánchez E, Rincon-Ramírez JJ, Moreno-Ordóñez DC, et al. Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test. Sci Rep. 2020 Dec 3;10(1):21118http://hdl.handle.net/10668/16728This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case-control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m2) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m2) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3-area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3-AUC levels were significantly elevated (p enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Angiopoietin-Like Protein 3Angiopoietin-like ProteinsBlood GlucoseDiabetes MellitusFastingGlucose Tolerance TestHumansInsulinInsulin ResistanceMaleObesityYoung Adultresearch article33273510open accessDiabetes mellitusGlucemiaProteina 3 similar a la angiopoyetinaPrueba de tolerancia a la glucosaResistencia a la insulinaAyunoInsulinaObesidad10.1038/s41598-020-77961-82045-2322PMC7713064https://www.nature.com/articles/s41598-020-77961-8.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713064/pdf