Velasco, InesCarreira, MonicaSantiago, PiedadMuela, José AntonioGarcía-Fuentes, EduardoSánchez-Muñoz, BaltasarGarriga, Maria JGonzález-Fernández, Maria CRodríguez, AlvaroCaballero, Francisco FMachado, AlbertoGonzález-Romero, StellaAnarte, Maria TSoriguer, Federico2013-10-072013-10-072009-09Velasco I, Carreira M, Santiago P, Muela JA, García-Fuentes E, Sánchez-Muñoz B, et al. Effect of iodine prophylaxis during pregnancy on neurocognitive development of children during the first two years of life. J. Clin. Endocrinol. Metab.. 2009; 94(9):3234-410021-972Xhttp://hdl.handle.net/10668/1316Journal Article; Research Support, Non-U.S. Gov't; "Comment in: What do we know about iodine supplementation in pregnancy? [J Clin Endocrinol Metab. 2009]" (Nota tomada de PubMed).CONTEXT The association between thyroid function during pregnancy and the later mental and psychomotor development of the child is supported by numerous experimental, clinical, and epidemiological studies. OBJECTIVE The aim of the study was to evaluate the psychological development of infants aged 3 to 18 months whose mothers had received 300 microg of potassium iodide during the first trimester of their pregnancy and compare with infants whose mothers had received no iodine supplements. DESIGN AND STUDY SUBJECTS: The study included 133 women who had received 300 microg of potassium iodine and 61 women who had received no iodine supplements. MAIN OUTCOME MEASURES The neuropsychological status of the children was evaluated with the Bayley Scales of Infant Development, and measurements were made of TSH, free T(3), free T(4), and urinary iodine. RESULTS Those children whose mothers had received an iodine supplement of 300 microg had a more favorable psychometric assessment than those of the other group of mothers. They had higher scores on the Psychomotor Development Index (P = 0.02) and the Behavior Rating Scale. CONCLUSIONS Dietary iodine supplements not only have no harmful effect on the neurodevelopment of the children, they may even be beneficial. Given the possible presence of confounding variables not controlled for in this study, these findings should be considered as preliminary.enSuplementos DietéticosCogniciónEmbarazoYodoGlándula TiroidesHormonas tiroideasMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Human Development::Child DevelopmentMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::CognitionMedical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Dietary SupplementsMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Named Groups::Persons::Age Groups::InfantMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Halogens::IodineMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::PregnancyMedical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Thyroid GlandMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Thyroid HormonesMedical Subject Headings::Named Groups::Persons::Age Groups::Adultresearch article19567536open access10.1210/jc.2008-26521945-7197