Gil-Cosano, Jose JGracia-Marco, LuisUbago-Guisado, EstherLabayen, IdoiaAdelantado-Renau, MireiaCadenas-Sanchez, CristinaMora-Gonzalez, JosePlaza-Florido, AbelAguilera, Concepcion MGomez-Vida, JoseMaldonado, JoseJurimae, JaakOrtega, Francisco B2023-01-252023-01-252019-08-16http://hdl.handle.net/10668/14481To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity. Plasma interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), epidermal growth factor, vascular endothelial growth factor A (VEGF), and C-reactive protein were analyzed in 55 children aged 8-11 years. A muscular fitness score was computed. Bone mineral content (BMC) of the total body-less head (TBLH) and lumbar spine (LS) were assessed using dual-energy x-ray absorptiometry. IL-6 (β = -0.136) and VEGF (β = -0.099) were associated with TBLH BMC, while TNF-α (β = -0.345) and IL-1β (β = 0.212) were associated with LS BMC (P  IL-6, VEGF, TNF-α, and IL-1β are significantly associated with bone mass. Higher muscular fitness may attenuate the adverse effect of high VEGF and TNF-α on bone mass.enAbsorptiometry, PhotonAge FactorsBiomarkersBone DensityChildCross-Sectional StudiesExercise TestFemaleHumansInflammation MediatorsMaleMuscle, SkeletalPediatric ObesityPhysical Fitnessresearch article31493774Restricted AccessAbsorciometria de fotonDensidad oseaMediadores de inflamaciónObesidad infantil10.1038/s41390-019-0572-81530-0447https://www.nature.com/articles/s41390-019-0572-8.pdf