Dioverti, VeronicaSalto-Alejandre, SonsolesHaidar, Ghady2023-05-032023-05-032022-11-12Dioverti V, Salto-Alejandre S, Haidar G. Immunocompromised Patients with Protracted COVID-19: a Review of "Long Persisters". Curr Transplant Rep. 2022;9(4):209-2182196-3029http://hdl.handle.net/10668/21731Certain immunocompromised individuals are at risk for protracted COVID-19, in which SARS-CoV-2 leads to a chronic viral infection. However, the pathogenesis, diagnosis, and management of this phenomenon remain ill-defined. Herein, we review key aspects of protracted SARS-CoV-2 infection in immunocompromised individuals, or the so-called long persisters, and describe the clinical presentation, risk factors, diagnosis, and treatment modalities of this condition, as well as intra-host viral evolution. Based on the available data, we also propose a framework of criteria with which to approach this syndrome. Protracted COVID-19 is an uncharacterized syndrome affecting patients with B-cell depletion; our proposed diagnostic approach and definitions will inform much needed future research.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19ImmunocompromisedProlonged COVID-19Prolonged sheddingSARS-CoV2HumansSARS-CoV-2COVID-19Risk FactorsCOVID-19 Testingresearch article36407883open accessSíndromeDiagnósticoFactores de riesgoPatogénesis homeopáticaInvestigaciónRiesgoPacientesTerapéuticaSARS-CoV-2Virosis10.1007/s40472-022-00385-yPMC9660019https://link.springer.com/content/pdf/10.1007/s40472-022-00385-y.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9660019/pdf