Baus-Dominguez, MariaGomez-Diaz, RaquelCorcuera-Flores, Jose-RamónTorres-Lagares, DanielRuiz-Villandiego, Jose-CruzMachuca-Portillo, GuillermoGutierrez-Perez, Jose-LuisSerrera-Figallo, Maria-Angeles2025-01-072025-01-072020-08-05Baus-Domínguez M, Gómez-Díaz R, Corcuera-Flores JR, Torres-Lagares D, Ruiz-Villandiego JC, Machuca-Portillo G, et al. Using Genetics in Periodontal Disease to Justify Implant Failure in Down Syndrome Patients. J Clin Med. 2020 Aug 5;9(8):2525.2077-0383https://hdl.handle.net/10668/27899Peri-implant bone loss leading to dental implant failure does not develop in the same way across subjects who apparently present the same condition-specifically, in the case of Down syndrome patients with the same genetic disorder-given that they do not necessarily develop immune-inflammatory disorders to the same extent. This retrospective case-control study was aimed at identifying the possible genes involved in implant failure in Down syndrome patients by matching the periodontal disease variable by means of a retrospective case-control study. This process involved using the functional analysis of gene expression software Transcriptome Analysis Console (TAC, Affymetrix, Thermo Fisher Scientific, Waltham, MA, USA) and a search for the possible candidate genes involved. Focus was placed on the 92 genes related to the inflammation identified from the TaqMan™ Array Plate Human Inflammation Kit (Thermo Fisher Scientific, Waltham, MA, USA). Six genes showed statistically significant results (p Statistically significant differences exist in the gene expression involved in osteoclastogenesis, inflammatory response and host defensive response.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Down syndromebone biologyclinical outcomesdental implantgene expressionosseointegrationperiodontal diseasesystemic diseaseHumansCase-Control StudiesRetrospective StudiesDental ImplantsDown SyndromeInflammationPeriodontal DiseasesGene Expression Profilingresearch article32764374open accessSíndrome de DownExpresión GénicaEnfermedades PeriodontalesHuesosEnfermedades Genéticas CongénitasPerfilación de la Expresión GénicaOsteogénesisImplantes Dentales10.3390/jcm9082525PMC7464703https://www.mdpi.com/2077-0383/9/8/2525/pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC7464703/pdf