Del Brutto, Oscar HMera, Robertino MCosta, Aldo FRecalde, Bettsy YCastillo, Pablo R2023-02-092023-02-092021http://hdl.handle.net/10668/17203This study assessed changes in sleep quality before and after the peak of the SARS-CoV-2 pandemic in community dwellers enrolled in the Atahualpa Project. Atahualpa residents aged ≥40 years were eligible if they had a Pittsburgh Sleep Quality Index (PSQI) 9 months before the pandemic and a lateral flow-based test for identification of SARS-CoV-2 antibodies during the peak of the pandemic. Six months later, individuals completed a follow-up PSQI. The independent relationship between SARS-CoV-2 infection and deterioration in sleep quality was assessed by fitting logistic mixed models for longitudinal data. Of 639 participants (mean age at baseline: 59 ± 12.8 years), 325 (51%) had SARS-CoV-2 antibodies. A total of 185 (29%) individuals at baseline and 311 (49%) at follow-up were poor sleepers (p This study shows a deleterious effect of SARS-CoV-2 in sleep quality. An effect of SARS-CoV-2 in disrupting sleep-related pathways cannot be ruled out. The Atahualpa Project has been registered at ClinicalTrials.gov; the identifier number is NCT01627600, and the date was: 10/02/2012 (https://clinicaltrials.gov/ct2/show/NCT01627600?cond=Atahualpa&draw=2&rank=1). The Sleep Disorders substudy has been registered at ClinicalTrials.gov; the identifier number is NCT01877616, and the date was: 06/13/2013 (https://clinicaltrials.gov/ct2/show/NCT01877616?cond=Atahualpa&draw=2&rank=4).enCOVID-19Coronavirus-19Pittsburgh Sleep Quality IndexSARS-CoV-2sleep qualityAgedCOVID-19EcuadorHumansMiddle AgedPandemicsProspective StudiesSARS-CoV-2Sleepresearch article33608714open access10.1093/sleep/zsab0411550-9109PMC7928566https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928566https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7928566/pdf