Pironi, LorisSteiger, EzraJoly, FranciscaWanten, Geert J AChambrier, CecileAimasso, UmbertoSasdelli, Anna SimonaSzczepanek, KingaJukes, AmeliaTheilla, MiriamKunecki, MarekDaniels, JoanneSerlie, Mireille JCooper, Sheldon CPoullenot, FlorianRasmussen, Henrik HøjgaardCompher, Charlene WCrivelli, AdrianaHughes, Sarah-JaneSantarpia, LidiaGuglielmi, Francesco WilliamRotovnik Kozjek, NadaEllegard, LarsSchneider, Stephane MMatras, PrzemysławForbes, AlastairWyer, NicolaZmarzly, AnnaTaus, MarinaO'Callaghan, MargieOsland, EmmaThibault, RonanCuerda, CristinaJones, LynnChapman, BrookeSahin, PeterVirgili, Nuria MLee, Andre Dong WonOrlandoni, PaoloMatysiak, KonradDi Caro, SimonaDoitchinova-Simeonova, MaryanaMasconale, LuisaSpaggiari, CorradoGarde, CarmenSerralde-Zuñiga, Aurora EOlveira, GabrielKrznaric, ZeljkoPetrina Jauregui, EstrellaZugasti Murillo, AnaSuarez-Llanos, Jose PNardi, ElenaVan Gossum, AndreLal, Simon2023-02-082023-02-082020-01-21Pironi L, Steiger E, Joly F, Wanten GJA, Chambrier C, Aimasso U, et al. Intravenous supplementation type and volume are associated with 1-year outcome and major complications in patients with chronic intestinal failure. Gut. 2020 Oct;69(10):1787-17950017-5749http://hdl.handle.net/10668/14982No marker to categorise the severity of chronic intestinal failure (CIF) has been developed. A 1-year international survey was carried out to investigate whether the European Society for Clinical Nutrition and Metabolism clinical classification of CIF, based on the type and volume of the intravenous supplementation (IVS), could be an indicator of CIF severity. At baseline, participating home parenteral nutrition (HPN) centres enrolled all adults with ongoing CIF due to non-malignant disease; demographic data, body mass index, CIF mechanism, underlying disease, HPN duration and IVS category were recorded for each patient. The type of IVS was classified as fluid and electrolyte alone (FE) or parenteral nutrition admixture (PN). The mean daily IVS volume, calculated on a weekly basis, was categorised as 3 L/day. The severity of CIF was determined by patient outcome (still on HPN, weaned from HPN, deceased) and the occurrence of major HPN/CIF-related complications: intestinal failure-associated liver disease (IFALD), catheter-related venous thrombosis and catheter-related bloodstream infection (CRBSI). Fifty-one HPN centres included 2194 patients. The analysis showed that both IVS type and volume were independently associated with the odds of weaning from HPN (significantly higher for PN 1 L/day), patients' death (lower for FE, p=0.079), presence of IFALD cholestasis/liver failure and occurrence of CRBSI (significantly higher for PN 2-3 and PN >3 L/day). The type and volume of IVS required by patients with CIF could be indicators to categorise the severity of CIF in both clinical practice and research protocols.enIntestinal failureLiver failureMotility disordersParenteral nutritionShort bowel syndromeAdministration, IntravenousAdultCatheter-Related InfectionsChronic DiseaseDrug Dosage CalculationsFat Emulsions, IntravenousFemaleFluid TherapyHumansIntestinal AbsorptionIntestinal DiseasesIntestinesLiver FailureMaleParenteral Nutrition, HomePharmaceutical SolutionsSeverity of Illness IndexResearch article31964752Restricted AccessEnfermedad crónicaEnfermedad de CrohnInformes de casosNeoplasiasEstudios transversalesConstricción patológicaPrueba de TuberculinaÍndice de severidad de la enfermedadDesnutrición10.1136/gutjnl-2018-3181721468-3288http://diposit.ub.edu/dspace/bitstream/2445/173794/3/PironiL.pdf