RT Journal Article
T1 Characterization of Metabolomic Profile Associated with Metabolic Improvement after Bariatric Surgery in Subjects with Morbid Obesity.
A1 Palau-Rodriguez, Magali
A1 Tulipani, Sara
A1 Marco-Ramell, Anna
A1 Miñarro, Antonio
A1 Jauregui, Olga
A1 Gonzalez-Dominguez, Raul
A1 Sanchez-Pla, Alex
A1 Ramos-Molina, Bruno
A1 Tinahones, Francisco J
A1 Andres-Lacueva, Cristina
K1 bariatric surgery
K1 hydroxyphenyllactic
K1 indole metabolites
K1 mass spectrometry
K1 metabolically healthy
K1 microbiota metabotype
K1 obesity
K1 untargeted metabolomics
AB The exact impact of bariatric surgery in metabolically "healthy" (MH) or "unhealthy" (MU) phenotypes for the study of the metabolic improvement is still unknown. We applied an untargeted LC-ESI-TripleTOF-MS-driven metabolomics approach in serum samples from 39 patients with morbid obesity (MH and MU) 1, 3, and 6 months after bariatric surgery. Multiple factor analysis, along with correlation and enrichment analyses, was carried out to distinguish those metabolites associated with metabolic improvement. Hydroxypropionic acids, medium-/long-chain hydroxy fatty acids, and bile acid glucuronides were the most discriminative biomarkers of response between MH and MU phenotypes. Hydroxypropionic (hydroxyphenyllactic-related) acids, amino acids, and glycerolipids were the most significant clusters of metabolites altered after bariatric surgery in MU ( p
YR 2018
FD 2018-06-29
LK http://hdl.handle.net/10668/12578
UL http://hdl.handle.net/10668/12578
LA en
DS RISalud
RD Apr 8, 2025