%0 Journal Article
%A Palau-Rodriguez, Magali
%A Tulipani, Sara
%A Marco-Ramell, Anna
%A Miñarro, Antonio
%A Jauregui, Olga
%A Gonzalez-Dominguez, Raul
%A Sanchez-Pla, Alex
%A Ramos-Molina, Bruno
%A Tinahones, Francisco J
%A Andres-Lacueva, Cristina
%T Characterization of Metabolomic Profile Associated with Metabolic Improvement after Bariatric Surgery in Subjects with Morbid Obesity.
%D 2018
%U http://hdl.handle.net/10668/12578
%X The exact impact of bariatric surgery in metabolically "healthy" (MH) or "unhealthy" (MU) phenotypes for the study of the metabolic improvement is still unknown. We applied an untargeted LC-ESI-TripleTOF-MS-driven metabolomics approach in serum samples from 39 patients with morbid obesity (MH and MU) 1, 3, and 6 months after bariatric surgery. Multiple factor analysis, along with correlation and enrichment analyses, was carried out to distinguish those metabolites associated with metabolic improvement. Hydroxypropionic acids, medium-/long-chain hydroxy fatty acids, and bile acid glucuronides were the most discriminative biomarkers of response between MH and MU phenotypes. Hydroxypropionic (hydroxyphenyllactic-related) acids, amino acids, and glycerolipids were the most significant clusters of metabolites altered after bariatric surgery in MU ( p
%K bariatric surgery
%K hydroxyphenyllactic
%K indole metabolites
%K mass spectrometry
%K metabolically healthy
%K microbiota metabotype
%K obesity
%K untargeted metabolomics
%~