RT Journal Article
T1 The Controversial Participation of GLP-1 in the Physiological Mechanisms Unchained After Bariatric Surgery
A1 Falckenheiner-Soria, Joshua
A1 Bancalero-De Los Reyes, Jose
A1 Moreno-Arciniegas, Alejandra
A1 Camacho-Ramirez, Alonso
A1 Arturo Prada-Oliveira, J.
A1 Perez-Arana, Gonzalo M.
K1 Pancreas: Diabetes
K1 Bariatric-surgery
K1 Insulin-Secreting Cells
K1 Enterohormones
K1 Duodenal-jejunal exclusion
K1 Sleeve gastrectomy
K1 Glucose-metabolism
K1 Gastric bypass
K1 Mouse models
K1 Secretion
K1 Hormones
K1 Therapy
K1 Weight
AB Numerous hypotheses are invoked to explain the beneficial effect on glucose metabolism after bariatric surgery. Some authors advocate for the secretion and release of various substances with endocrine functions (enterohormones). One of the substances most marked as effector, with contrasting effects but controversial data, is Glucagon-like peptide-1 GLP-1. Our study was performed in healthy male Wistar rats, to avoid the absence of confounding factors such as DMT2 and obesity. In order to know the map of adaptation to GLP-1 secretion after surgery, five groups were designated: Two control groups (fasting and surgical stress); and three surgical groups (vertical sleeve gastrectomy, 50 % midgut resection and Roux-en-Y gastric bypass). After three months, the GLP-1 synthesis pattern was studied by immunohistochemical techniques in the different portions of the small digestive tract. The expression of membrane receptors in pancreatic islet cells was also studied. There was a significant increase in the number of secretory cells in ileum, duodenum and jejunum in mixed surgical (RYGB) and malabsorptive (RI50) groups. An elevation of pancreatic receptors was also observed in the same techniques against controls. Our data indicated that intestinal secretion of GLP-1 and its sensitivity to the pancreatic level were increased, both to an adaptive effect to the mechanical aggression of the digestive tube and to the alteration of nutrient flow after surgery.
PB Soc chilena anatomia
SN 0717-9502
YR 2019
FD 2019-01-01
LK http://hdl.handle.net/10668/19351
UL http://hdl.handle.net/10668/19351
LA es
DS RISalud
RD Apr 6, 2025