RT Journal Article T1 Nut intake and 5-year changes in body weight and obesity risk in adults: results from the EPIC-PANACEA study. A1 Freisling, Heinz A1 Noh, Hwayoung A1 Slimani, Nadia A1 Chajès, Véronique A1 May, Anne M A1 Peeters, Petra H A1 Weiderpass, Elisabete A1 Cross, Amanda J A1 Skeie, Guri A1 Jenab, Mazda A1 Mancini, Francesca R A1 Boutron-Ruault, Marie-Christine A1 Fagherazzi, Guy A1 Katzke, Verena A A1 Kühn, Tilman A1 Steffen, Annika A1 Boeing, Heiner A1 Tjønneland, Anne A1 Kyrø, Cecilie A1 Hansen, Camilla P A1 Overvad, Kim A1 Duell, Eric J A1 Redondo-Sánchez, Daniel A1 Amiano, Pilar A1 Navarro, Carmen A1 Barricarte, Aurelio A1 Perez-Cornago, Aurora A1 Tsilidis, Konstantinos K A1 Aune, Dagfinn A1 Ward, Heather A1 Trichopoulou, Antonia A1 Naska, Androniki A1 Orfanos, Philippos A1 Masala, Giovanna A1 Agnoli, Claudia A1 Berrino, Franco A1 Tumino, Rosario A1 Sacerdote, Carlotta A1 Mattiello, Amalia A1 Bueno-de-Mesquita, H Bas A1 Ericson, Ulrika A1 Sonestedt, Emily A1 Winkvist, Anna A1 Braaten, Tonje A1 Romieu, Isabelle A1 Sabaté, Joan K1 Adults K1 Energy balance K1 Europe K1 Nut intake K1 Obesity K1 Weight gain AB There is inconsistent evidence regarding the relationship between higher intake of nuts, being an energy-dense food, and weight gain. We investigated the relationship between nut intake and changes in weight over 5 years. This study includes 373,293 men and women, 25-70 years old, recruited between 1992 and 2000 from 10 European countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Habitual intake of nuts including peanuts, together defined as nut intake, was estimated from country-specific validated dietary questionnaires. Body weight was measured at recruitment and self-reported 5 years later. The association between nut intake and body weight change was estimated using multilevel mixed linear regression models with center/country as random effect and nut intake and relevant confounders as fixed effects. The relative risk (RR) of becoming overweight or obese after 5 years was investigated using multivariate Poisson regressions stratified according to baseline body mass index (BMI). On average, study participants gained 2.1 kg (SD 5.0 kg) over 5 years. Compared to non-consumers, subjects in the highest quartile of nut intake had less weight gain over 5 years (-0.07 kg; 95% CI -0.12 to -0.02) (P trend = 0.025) and had 5% lower risk of becoming overweight (RR 0.95; 95% CI 0.92-0.98) or obese (RR 0.95; 95% CI 0.90-0.99) (both P trend Higher intake of nuts is associated with reduced weight gain and a lower risk of becoming overweight or obese. YR 2017 FD 2017-07-21 LK http://hdl.handle.net/10668/11430 UL http://hdl.handle.net/10668/11430 LA en DS RISalud RD Apr 6, 2025