TY  - JOUR
AU  - Schellenberg, Matthew J
AU  - Lieberman, Jenna Ariel
AU  - Herrero-Ruiz, Andrés
AU  - Butler, Logan R
AU  - Williams, Jason G
AU  - Muñoz-Cabello, Ana M
AU  - Mueller, Geoffrey A
AU  - London, Robert E
AU  - Cortés-Ledesma, Felipe
AU  - Williams, R Scott
PY  - 2017
DO  - 10.1126/science.aam6468
UR  - http://hdl.handle.net/10668/11582
T2  - Science (New York, N.Y.)
AB  - Topoisomerase 2 (TOP2) DNA transactions proceed via formation of the TOP2 cleavage complex (TOP2cc), a covalent enzyme-DNA reaction intermediate that is vulnerable to trapping by potent anticancer TOP2 drugs. How genotoxic TOP2 DNA-protein cross-links...
LA  - en
KW  - Aminoacyltransferases
KW  - Animals
KW  - Bacterial Proteins
KW  - Biocatalysis
KW  - Catalytic Domain
KW  - DNA
KW  - DNA Damage
KW  - DNA Repair
KW  - DNA Topoisomerases, Type II
KW  - DNA-Binding Proteins
KW  - Etoposide
KW  - Gene Knockdown Techniques
KW  - HEK293 Cells
KW  - Humans
KW  - Immunoprecipitation
KW  - Luminescent Proteins
KW  - Mice
KW  - Nuclear Proteins
KW  - Phosphoric Diester Hydrolases
KW  - Recombinant Proteins
KW  - Saccharomyces cerevisiae Proteins
KW  - Small Ubiquitin-Related Modifier Proteins
KW  - Sumoylation
KW  - Topoisomerase II Inhibitors
KW  - Transcription Factors
KW  - Ubiquitin-Protein Ligases
TI  - ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.
TY  - research article
VL  - 357
ER  -