TY - JOUR AU - Schellenberg, Matthew J AU - Lieberman, Jenna Ariel AU - Herrero-Ruiz, Andres AU - Butler, Logan R AU - Williams, Jason G AU - Muñoz-Cabello, Ana M AU - Mueller, Geoffrey A AU - London, Robert E AU - Cortes-Ledesma, Felipe AU - Williams, R Scott PY - 2017 DO - 10.1126/science.aam6468 UR - http://hdl.handle.net/10668/11582 T2 - Science (New York, N.Y.) AB - Topoisomerase 2 (TOP2) DNA transactions proceed via formation of the TOP2 cleavage complex (TOP2cc), a covalent enzyme-DNA reaction intermediate that is vulnerable to trapping by potent anticancer TOP2 drugs. How genotoxic TOP2 DNA-protein cross-links... LA - en PB - American Association for the Advancement of Science (AAAS) KW - TOP2 cleavage complex resolution KW - SUMOylation in DNA repair KW - ZATT-TDP2 signaling axis KW - Non-proteasomal DNA-protein crosslink repair KW - SUMO2 engagement platform KW - Anticancer drug-induced genotoxicity KW - Aminoacyltransferases KW - Animals KW - Bacterial Proteins KW - Biocatalysis KW - Catalytic Domain KW - DNA KW - DNA Damage KW - DNA Repair KW - DNA Topoisomerases, Type II KW - DNA-Binding Proteins KW - Etoposide KW - Gene Knockdown Techniques KW - HEK293 Cells KW - Humans KW - Immunoprecipitation KW - Luminescent Proteins KW - Mice KW - Nuclear Proteins KW - Phosphoric Diester Hydrolases KW - Recombinant Proteins KW - Saccharomyces cerevisiae Proteins KW - Small Ubiquitin-Related Modifier Proteins KW - Sumoylation KW - Topoisomerase II Inhibitors KW - Transcription Factors KW - Ubiquitin-Protein Ligases TI - ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links. TY - research article VL - 357 ER -