RT Journal Article
T1 Evolution of impulsivity levels in relation to early cannabis use in violent patients in the early phase of psychosis.
A1 Dan-Glauser, Elise
A1 Framorando, David
A1 Solida-Tozzi, Alessandra
A1 Golay, Philippe
A1 Gholam, M Mehdi
A1 Alameda, Luis
A1 Conus, Philippe
A1 Moulin, Valerie
K1 Cannabis use
K1 early cannabis use
K1 early-phase psychosis
K1 impulsivity
K1 violent behavior
AB Prevention of violent behaviors (VB) in the early phase of psychosis (EPP) is a real challenge. Impulsivity was shown to be strongly related to VB, and different evolutions of impulsivity were noticed along treatments. One possible variable involved in the relationship between VB and the evolution of impulsivity is cannabis use (CU). The high prevalence of CU in EPP and its relationship with VB led us to investigate: 1/the impact of CU and 2/the impact of early CU on the evolution of impulsivity levels during a 3-year program, in violent and non-violent EPP patients. 178 non-violent and 62 violent patients (VPs) were followed-up over a 3 year period. Age of onset of CU was assessed at program entry and impulsivity was assessed seven times during the program. The evolution of impulsivity level during the program, as a function of the violent and non-violent groups of patients and CU precocity were analyzed with linear mixed-effects models. Over the treatment period, impulsivity level did not evolve as a function of the interaction between group and CU (coef. = 0.02, p = 0.425). However, when including precocity of CU, impulsivity was shown to increase significantly only in VPs who start consuming before 15 years of age (coef. = 0.06, p = 0.008). The precocity of CU in VPs seems to be a key variable of the negative evolution of impulsivity during follow-up and should be closely monitored in EPP patients entering care since they have a higher risk of showing VB.
YR 2022
FD 2022-02-10
LK http://hdl.handle.net/10668/22573
UL http://hdl.handle.net/10668/22573
LA en
DS RISalud
RD Apr 8, 2025