RT Journal Article
T1 Omega-3 LCPUFA supplement: a nutritional strategy to prevent maternal and neonatal oxidative stress
A1 Kajarabille, Naroa
A1 Hurtado, Jose A.
A1 Pena-Quintana, Luis
A1 Pena, Manuela
A1 Ruiz, Josefa
A1 Diaz-Castro, Javier
A1 Rodriguez-Santana, Yessica
A1 Martin-Alvarez, Estefania
A1 Lopez-Frias, Magdalena
A1 Soldado, Olga
A1 Lara-Villoslada, Federico
A1 Ochoa, Julio J.
K1 docosahexaenoic acid (DHA)
K1 n-3 fatty acids
K1 pregnancy
K1 infant development
K1 oxidative stress
K1 antioxidant defence
K1 Polyunsaturated fatty-acids
K1 Randomized controlled-trial
K1 Docosahexaenoic acid
K1 Pregnant-women
K1 Preterm labor
K1 Visual-acuity
K1 Term infants
K1 Omega-3-fatty-acids
K1 Enhance
K1 Neurodevelopment
AB There is controversy about fish-oil supplementation and oxidative damage. This ambiguity should be explored to elucidate its role as modulator of oxidative stress, especially during gestation and postnatal life. This is the objective of this study. One hundred ten pregnant women were divided in two groups: control group CT (400mL/day of the control dairy drink); supplemented group FO (400mL/day of the fish oil-enriched dairy drink (+/- 400-mg EPA-DHA/day)). Different biomarkers of oxidative damage were determined in the mother's at enrolment, at delivery and at 2.5 and 4months postpartum and newborns at delivery and at 2.5months postpartum. Omega-3 LC-PUFA supplementation during pregnancy and lactation decreased plasma hydroperoxides especially in newborn at delivery (P=0.001) and 2.5months (P=0.006), increased superoxide dismutase (SOD) and catalase (CAT) in mothers at delivery (P=0.024 (SOD)) and after 2.5months (P=0.040 (CAT)) and in newborns at 2.5months (P=0.035 (SOD); P=0.021 (CAT)). Also, supplementation increased -tocoferol in mothers at 2.5months (P=0.030) and in umbilical cord artery (P=0.039). Higher levels of CoQ10 were found in mothers at delivery (P=0.039) as well as in umbilical cord vein (P=0.024) and artery (P=0.036). Our supplementation prevents the oxidative stress in the mother and neonate during the first months of postnatal life, being a potential preventive nutritional strategy to prevent functional alterations associated with oxidative stress that have an important repercussion for the neonate development in the early postnatal life.
PB Wiley
SN 1740-8695
YR 2017
FD 2017-04-01
LK http://hdl.handle.net/10668/18994
UL http://hdl.handle.net/10668/18994
LA en
DS RISalud
RD Apr 11, 2025