RT Journal Article
T1 Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions.
A1 Kostaki, Evangelia-Georgia
A1 Flampouris, Andreas
A1 Karamitros, Timokratis
A1 Chueca, Natalia
A1 Alvarez, Marta
A1 Casas, Paz
A1 Alejos, Belen
A1 Hatzakis, Angelos
A1 Garcia, Federico
A1 Paraskevis, Dimitrios
A1 CoRIS, 
K1 CRF02_AG
K1 HIV-1
K1 Spain
K1 regional dispersal
K1 spatiotemporal characteristics
AB Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41-6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain. Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000-2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively. Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p
SN 1664-302X
YR 2019
FD 2019-03-11
LK https://hdl.handle.net/10668/26236
UL https://hdl.handle.net/10668/26236
LA en
DS RISalud
RD Apr 10, 2025