%0 Journal Article
%A Kostaki, Evangelia-Georgia
%A Flampouris, Andreas
%A Karamitros, Timokratis
%A Chueca, Natalia
%A Alvarez, Marta
%A Casas, Paz
%A Alejos, Belen
%A Hatzakis, Angelos
%A Garcia, Federico
%A Paraskevis, Dimitrios
%A CoRIS
%T Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions.
%D 2019
%@ 1664-302X
%U https://hdl.handle.net/10668/26236
%X Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41-6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain. Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000-2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively. Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p
%K CRF02_AG
%K HIV-1
%K Spain
%K regional dispersal
%K spatiotemporal characteristics
%~