RT Journal Article
T1 A nutritional intervention study with hydrolyzed collagen in pre-pubertal Spanish children: influence on bone modeling biomarkers
A1 Martin-Bautista, Elena
A1 Martin-Matillas, Miguel
A1 Martin-Lagos, Jose A.
A1 Miranda-Leon, M\ Teresa
A1 Muñoz-Torres, Manuel
A1 Ruiz-Requena, Estrella
A1 Rivero, M.
A1 Quer, Josefa
A1 Puigdueta, Isabel
A1 Campoy, Cristina
K1 Bone
K1 Children
K1 Protein
K1 Proteínas en la Dieta
K1 Colágeno Tipo I
K1 Marcadores Biológicos
K1 Fosfatasa Alcalina
K1 Niño
K1 Remodelación Ósea
K1 Proteínas en la Dieta
K1 Pruebas de Química Clínica
K1 Fuerza de la Mano
K1 Dieta
K1 Hidrólisis
K1 Femenino
K1 Masculino
K1 Humano
K1 España
K1 Pubertad
AB Aim: The aim of the study was to investigate the influence of dietary intake of commercial hydrolyzed collagen (Gelatine Royal ®) on bone remodeling in pre-pubertal children.Methods: A randomized double-blind study was carried out in 60 children (9.42 ± 1.31 years) divided into three groups according to the amount of partially hydrolyzed collagen taken daily for 4 months: placebo (G-I, n = 18), collagen (G-II, n = 20) and collagen + calcium (G-III, n = 22) groups. Analyses of the following biochemical markers were carried out: total and bone alkaline phosphatase (tALP and bALP), osteocalcin, tartrate-resistant acid phosphatase (TRAP), type I collagen carboxy terminal telopeptide, lipids, calcium, 25-hydroxyvitamin D, insulin-like growth factor 1 (IGF-1), thyroid-stimulating hormone, free thyroxin and intact parathormone.Results: There was a significantly greater increase in serum IGF-1 in G-III than in G II (p < 0.01) or G-I (p < 0.05) during  the study period, and a significantly greater increase in plasma tALP in G-III than in G-I (p < 0.05). Serum bALP behavior significantly (p < 0.05) differed between G-II (increase) and G-I (decrease). Plasma TRAP behavior significantly differed between G-II and G-I (p < 0.01) and between G-III and G-II (p < 0.05).Conclusion: Daily dietary intake of hydrolyzed collagen seems to have a potential role in enhancing bone remodeling at key stages of growth and development.
PB Walter de Gruyter
SN 0334-018X
YR 2011
FD 2011-04
LK http://hdl.handle.net/10668/1484
UL http://hdl.handle.net/10668/1484
LA en
NO Martin-Bautista E, Martin-Matillas M, Martin-Lagos JA, Miranda-Leon MT, Muñoz-Torres M, Ruiz-Requena E, et al. A nutritional intervention study with hydrolyzed collagen in pre-pubertal spanish children: influence on bone modeling biomarkers. J. Pediatr. Endocrinol. Metab. 2011; 24(3-4):147-53
NO Journal Article; Randomized Controlled Trial.
DS RISalud
RD Mar 5, 2025