%0 Journal Article
%A Martin-Bautista, Elena
%A Martin-Matillas, Miguel
%A Martin-Lagos, Jose A.
%A Miranda-Leon, M\ Teresa
%A Muñoz-Torres, Manuel
%A Ruiz-Requena, Estrella
%A Rivero, M.
%A Quer, Josefa
%A Puigdueta, Isabel
%A Campoy, Cristina
%T A nutritional intervention study with hydrolyzed collagen in pre-pubertal Spanish children: influence on bone modeling biomarkers
%D 2011
%@ 0334-018X
%U http://hdl.handle.net/10668/1484
%X Aim: The aim of the study was to investigate the influence of dietary intake of commercial hydrolyzed collagen (Gelatine Royal ®) on bone remodeling in pre-pubertal children.Methods: A randomized double-blind study was carried out in 60 children (9.42 ± 1.31 years) divided into three groups according to the amount of partially hydrolyzed collagen taken daily for 4 months: placebo (G-I, n = 18), collagen (G-II, n = 20) and collagen + calcium (G-III, n = 22) groups. Analyses of the following biochemical markers were carried out: total and bone alkaline phosphatase (tALP and bALP), osteocalcin, tartrate-resistant acid phosphatase (TRAP), type I collagen carboxy terminal telopeptide, lipids, calcium, 25-hydroxyvitamin D, insulin-like growth factor 1 (IGF-1), thyroid-stimulating hormone, free thyroxin and intact parathormone.Results: There was a significantly greater increase in serum IGF-1 in G-III than in G II (p < 0.01) or G-I (p < 0.05) during  the study period, and a significantly greater increase in plasma tALP in G-III than in G-I (p < 0.05). Serum bALP behavior significantly (p < 0.05) differed between G-II (increase) and G-I (decrease). Plasma TRAP behavior significantly differed between G-II and G-I (p < 0.01) and between G-III and G-II (p < 0.05).Conclusion: Daily dietary intake of hydrolyzed collagen seems to have a potential role in enhancing bone remodeling at key stages of growth and development.
%K Bone
%K Children
%K Protein
%K Proteínas en la Dieta
%K Colágeno Tipo I
%K Marcadores Biológicos
%K Fosfatasa Alcalina
%K Niño
%K Remodelación Ósea
%K Proteínas en la Dieta
%K Pruebas de Química Clínica
%K Fuerza de la Mano
%K Dieta
%K Hidrólisis
%K Femenino
%K Masculino
%K Humano
%K España
%K Pubertad
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