RT Journal Article
T1 Effect of time of day of recreational and household physical activity on prostate and breast cancer risk (MCC-Spain study).
A1 Weitzer, Jakob
A1 Castaño-Vinyals, Gemma
A1 Aragonés, Nuria
A1 Gómez-Acebo, Inés
A1 Guevara, Marcela
A1 Amiano, Pilar
A1 Martín, Vicente
A1 Molina-Barceló, Ana
A1 Alguacil, Juan
A1 Moreno, Victor
A1 Suarez-Calleja, Claudia
A1 Jiménez-Moleón, José Juan
A1 Marcos-Gragera, Rafael
A1 Papantoniou, Kyriaki
A1 Pérez-Gómez, Beatriz
A1 Llorca, Javier
A1 Ascunce, Nieves
A1 Gil, Leire
A1 Gracia-Lavedan, Esther
A1 Casabonne, Delphine
A1 Lope, Virginia
A1 Pollán, Marina
A1 Kogevinas, Manolis
K1 breast
K1 cancer
K1 circadian disruption
K1 physical activity
K1 prostate
AB Experimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population-based case-control study (MCC-Spain) if the time-of-day when physical activity is done affects prostate and breast cancer risk. Lifetime recreational and household physical activity was assessed by in-person interviews. Information on time-of-day of activity (assessed approximately 3 years after the assessment of lifetime physical activity and confounders) was available for 781 breast cancer cases, 865 population female controls, 504 prostate cases and 645 population male controls from 10 Spanish regions, 2008-2013. We estimated odds ratios (ORs) and 95% confidence intervals (95% CI) for different activity timings compared to inactive subjects using unconditional logistic regression adjusting for confounders. Early morning (8-10 am) activity was associated with a protective effect compared to no physical activity for both breast (OR = 0.74, 95% CI = 0.48-1.15) and prostate cancer (OR = 0.73, 95% CI = 0.44-1.20); meta-OR for the two cancers combined 0.74 (95%CI = 0.53-1.02). There was no effect observed for breast or prostate cancer for late morning to afternoon activity while a protective effect was also observed for evening activity only for prostate cancer (OR = 0.75, 95% CI = 0.45-1.24). Protective effects of early morning activity were more pronounced for intermediate/evening chronotypes for both cancers. This is the first population-based investigation identifying a differential effect of timing of physical activity on cancer risk with more pronounced effects for morning hour activity. Our results, if confirmed, may improve current physical activity recommendations for cancer prevention.
YR 2020
FD 2020-10-07
LK http://hdl.handle.net/10668/16315
UL http://hdl.handle.net/10668/16315
LA en
DS RISalud
RD Apr 9, 2025