RT Journal Article
T1 Sex-Dependent Aggregation of Tinnitus in Swedish Families.
A1 Trpchevska, Natalia
A1 Bulla, Jan
A1 Prada Hellberg, Matilda
A1 Edvall, Niklas K
A1 Lazar, Andra
A1 Mehraei, Golbarg
A1 Uhlen, Inger
A1 Schlee, Winfried
A1 Canlon, Barbara
A1 Gallus, Silvano
A1 Lopez-Escamez, Jose Antonio
A1 Cederroth, Christopher R
K1 bilateral
K1 constant
K1 familial aggregation
K1 genetic risk
K1 hearing loss
K1 tinnitus
K1 unilateral
AB Twin and adoption studies point towards a genetic contribution to tinnitus; however, how the genetic risk applies to different forms of tinnitus is poorly understood. Here, we perform a familial aggregation study and determine the relative recurrence risk for tinnitus in siblings (λs). Four different Swedish studies (N = 186,598) were used to estimate the prevalence of self-reported bilateral, unilateral, constant, and severe tinnitus in the general population and we defined whether these 4 different forms of tinnitus segregate in families from the Swedish Tinnitus Outreach Project (STOP, N = 2305). We implemented a percentile bootstrap approach to provide accurate estimates and confidence intervals for λs. We reveal a significant λs for all types of tinnitus, the highest found being 7.27 (95% CI (5.56-9.07)) for severe tinnitus, with a higher susceptibility in women (10.25; 95% CI (7.14-13.61)) than in men (5.03; 95% CI (3.22-7.01)), suggesting that severity may be the most genetically influenced trait in tinnitus in a sex-dependent manner. Our findings strongly support the notion that genetic factors impact on the development of tinnitus, more so for severe tinnitus. These findings highlight the importance of considering tinnitus severity and sex in the design of large genetic studies to optimize diagnostic approaches and ultimately improve therapeutic interventions.
SN 2077-0383
YR 2020
FD 2020-11-25
LK https://hdl.handle.net/10668/28436
UL https://hdl.handle.net/10668/28436
LA en
DS RISalud
RD Aug 9, 2025