%0 Journal Article
%A Troulé, Kevin
%A López-Fernández, Hugo
%A García-Martín, Santiago
%A Reboiro-Jato, Miguel
%A Carretero-Puche, Carlos
%A Martorell-Marugán, Jordi
%A Martín-Serrano, Guillermo
%A Carmona-Sáez, Pedro
%A Glez-Peña, Daniel
%A Al-Shahrour, Fátima
%A Gómez-López, Gonzalo
%T DREIMT: a drug repositioning database and prioritization tool for immunomodulation.
%D 2021
%U http://hdl.handle.net/10668/16121
%X Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases. DREIMT is a new hypothesis-generation web tool, which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4960 drug profiles and ∼2600 immune gene expression signatures. The tool also suggests potential immunomodulatory drugs targeting user-supplied gene expression signatures. Final output includes drug-signature association scores, FDRs and downloadable plots and results tables. http://www.dreimt.org. Supplementary data are available at Bioinformatics online.
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