RT Journal Article
T1 Salivary Cortisol Levels Are Associated with Craving and Cognitive Performance in Cocaine-Abstinent Subjects: A Pilot Study
A1 Sampedro-Piquero, Patricia
A1 Vicario, Selene
A1 Pérez-Rivas, Aroha
A1 Venero, César
A1 Baliyan, Shishir
A1 Santín, Luis Javier
K1 Addiction
K1 Cocaine
K1 Cognition
K1 Cortisol
K1 Craving
K1 Hypothalamic-pituitary-adrenal (HPA)
K1 Memory
K1 Cocaína
K1 Cognición
K1 Hidrocortisona
K1 Ansia
K1 Memoria
K1 Andalucía
K1 Proyectos piloto
AB Cortisol is a glucocorticoid hormone secreted by the adrenal cortex upon the activation of the hypothalamic-pituitary-adrenal (HPA) axis. Assessment of cortisol in saliva has emerged as a reliable way of evaluating HPA function. We examined the relationships between salivary cortisol levels with both craving and cognitive performance, as a possible biomarker of cocaine addiction. Cognitive performance (attention, declarative and working memory, executive functions and recognition of emotions) was assessed in 14 abstinent cocaine-dependent subjects in outpatient treatment and 13 control participants. Three salivary samples were collected at home by all the participants in the morning, afternoon and at bedtime. Patients showed higher levels of cortisol in the morning, as well as higher area under the curve with respect to the ground (AUCg). Regarding cognitive performance, cocaine-abstinent subjects showed worse performance in attention (d2 test), verbal memory (Spanish Complementary Verbal Learning Test, TAVEC) and executive tests (Tower of Hanoi and phonological fluency test) with respect to the control group. Morning cortisol levels and the AUCg index were negatively associated with the age of onset of drug consumption and the AUCg index was also positively associated with craving in our patients' group. Moreover, morning cortisol levels, as well as the AUCg index, were negatively associated with verbal memory performance. Therefore, our pilot study suggests that salivary cortisol measurements could be a good avenue to predict craving level, as well as cognitive status, especially the declarative memory domain.
PB MDPI
YR 2020
FD 2020-09-27
LK http://hdl.handle.net/10668/3767
UL http://hdl.handle.net/10668/3767
LA en
NO Sampedro-Piquero P, Vicario S, Pérez-Rivas A, Venero C, Baliyan S, Santín LJ. Salivary Cortisol Levels Are Associated with Craving and Cognitive Performance in Cocaine-Abstinent Subjects: A Pilot Study. Brain Sci. 2020 Sep 27;10(10):682
DS RISalud
RD Apr 11, 2025