%0 Journal Article
%A Torres, Antoni
%A Motos, Ana
%A Cilloniz, Catia
%A Ceccato, Adrian
%A Fernandez-Barat, Laia
%A Gabarrus, Albert
%A Bermejo-Martin, Jesus
%A Ferrer, Ricard
%A Riera, Jordi
%A Perez-Arnal, Raquel
%A Garcia-Gasulla, Dario
%A Peñuelas, Oscar
%A Lorente, Josa Angel
%A de Gonzalo-Calvo, David
%A Almansa, Raquel
%A Menendez, Rosario
%A Palomeque, Andrea
%A Villar, Rosario Amaya
%A Añon, Jose M
%A Balan Mariño, Ana
%A Barbera, Carme
%A Barberan, Jose
%A Blandino Ortiz, Aaron
%A Boado, Maria Victoria
%A Bustamante-Munguira, Elena
%A Caballero, Jesus
%A Canton-Bulnes, Maria Luisa
%A Carbajales Perez, Cristina
%A Carbonell, Nieves
%A Catalan-Gonzalez, Mercedes
%A de Frutos, Raul
%A Franco, Nieves
%A Galban, Cristóbal
%A Gumucio-Sanguino, Víctor D
%A de la Torre, Maria Del Carmen
%A Diaz, Emili
%A Estella, Angel
%A Gallego, Elena
%A Garcia Garmendia, Jose Luis
%A Gomez, Jose M
%A Huerta, Arturo
%A Garcia, Ruth Noemi Jorge
%A Loza-Vazquez, Ana
%A Marin-Corral, Judith
%A Martin Delgado, Maria Cruz
%A Martinez de la Gandara, Amalia
%A Martinez Varela, Ignacio
%A Lopez Messa, Juan
%A Albaiceta, Guillermo M
%A Nieto, Maite
%A Novo, Mariana Andrea
%A Peñasco, Yhivian
%A Perez-Garcia, Felipe
%A Pozo-Laderas, Juan Carlos
%A Ricart, Pilar
%A Sagredo, Victor
%A Sanchez-Miralles, Angel
%A Sancho Chinesta, Susana
%A Serra-Fortuny, Mireia
%A Socias, Lorenzo
%A Sole-Violan, Jordi
%A Suarez-Sipmann, Fernando
%A Tamayo Lomas, Luis
%A Trenado, Jose
%A Ubeda, Alejandro
%A Valdivia, Luis Jorge
%A Vidal, Pablo
%A Barbe, Ferran
%T Major candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study.
%D 2022
%U http://hdl.handle.net/10668/19575
%X Although there is evidence supporting the benefits of corticosteroids in patients affected with severe coronavirus disease 2019 (COVID-19), there is little information related to their potential benefits or harm in some subgroups of patients admitted to the intensive care unit (ICU) with COVID-19. We aim to investigate to find candidate variables to guide personalized treatment with steroids in critically ill patients with COVID-19. Multicentre, observational cohort study including consecutive COVID-19 patients admitted to 55 Spanish ICUs. The primary outcome was 90-day mortality. Subsequent analyses in clinically relevant subgroups by age, ICU baseline illness severity, organ damage, laboratory findings and mechanical ventilation were performed. High doses of corticosteroids (≥ 12 mg/day equivalent dexamethasone dose), early administration of corticosteroid treatment ( Between February 2020 and October 2021, 4226 patients were included. Of these, 3592 (85%) patients had received systemic corticosteroids during hospitalisation. In the propensity-adjusted multivariable analysis, the use of corticosteroids was protective for 90-day mortality in the overall population (HR 0.77 [0.65-0.92], p = 0.003) and in-hospital mortality (SHR 0.70 [0.58-0.84], p  Corticosteroid in ICU-admitted patients with COVID-19 may be administered based on age, severity, baseline inflammation, and invasive mechanical ventilation. Early administration since symptom onset may prove harmful.
%K COVID-19
%K Corticosteroids
%K Critically ill
%K Intensive care
%~